| Gene Symbol |
Muc4
|
| Entrez Gene |
140474
|
| Alt Symbol |
4933405I11Rik, Asgp
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mucin 4
|
| Other Description |
ascites sialoglycoprotein|mucin 4, ASGP|mucin-4|pancreatic adenocarcinoma mucin|testis mucin
|
| Swissprots |
Q8JZM8 Q4VAA3 Q9ERB8 Q9QXG0 Q9WV36
|
| Accessions |
AAG17440 AAM66746 Q8JZM8 AF161256 AAD43349 AF218265 AAF23818 AF218819 AAF25480 AF441786 AAM66254 AK016665 BAC25492 AY007202 AAG02256 BC096477 AAH96477 BP765127 BP765128 CB522483 NM_080457 NP_536705 NM_183101
|
| Function |
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 "Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass membrane protein. Secreted. Note=Secreted by proteolytic processing. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in trachea, duodenum and intestine. Lower expression in stomach, salivary glands, liver, gallbladder, and kidney. {ECO:0000269|PubMed:12084055}.
|