| Gene Symbol |
Trim9
|
| Entrez Gene |
155812
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif-containing 9
|
| Other Description |
E3 ubiquitin-protein ligase TRIM9|SNAP-25-interacting RING finger protein|Spring|tripartite motif protein 9|tripartite motif-containing protein 9
|
| Swissprots |
Q91ZY8
|
| Accessions |
EDM03547 EDM03548 EDM03549 Q91ZY8 AF350422 AAL27988 XM_008764691 XP_008762913 XM_008764692 XP_008762914 XM_008764693 XP_008762915 XM_008764694 XP_008762916 NM_130420 NP_569104
|
| Function |
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions (By similarity). May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Cytoplasm, cytoskeleton. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (By similarity). Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton. {ECO:0000250}.
|
| Tissue Specificity |
Brain (at protein level). Expressed in fetal and adult brain. {ECO:0000269|PubMed:20085810}.
|