IGF1R

Gene Symbol IGF1R
Entrez Gene 281848
Alt Symbol IGFR1
Species Bovine
Gene Type protein-coding
Description insulin-like growth factor 1 receptor
Other Description IGF-I receptor|insulin-like growth factor I receptor
Swissprots Q05688
Accessions AAB52601 DAA17722 Q05688 CV979948 CX952835 EE901083 EH174755 HQ703508 AEX15867 X54980 CAA38724 XM_010816884 XP_010815186 NM_001244612 NP_001231541
Function Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma

Insulin-like growth factor 1 receptor (IGF1R), Bovine, ELISA Kit - E11I0430 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Insulin-like growth factor 1 receptor, IGF1R, Bovine, ELISA Kit - E1200b from ARP American Research Products

Category ELISA Kit
Prices $736.00
Sizes 96 t

insulin-like growth factor 1 receptor, ELISA Kit - MBS706941 from MyBioSource

Category ELISA Kit
Prices $550.00, $795.00, $2,890.00, $5,465.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of goat IGF1R is typically less than 0.078 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 0.312 ng/ml -20 ng/ml.

Bovine IGF1R ELISA Kit - E086415 from Biobool

Category ELISA Kit

Insulin-like growth factor 1 receptor, ELISA Kit - MBS289379 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 78.0pg/mL -5000pg/mL.

Insulin-like growth factor 1 receptor (IGF1R), ELISA Kit - MBS287000 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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