| Gene Symbol |
IGF1R
|
| Entrez Gene |
281848
|
| Alt Symbol |
IGFR1
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor 1 receptor
|
| Other Description |
IGF-I receptor|insulin-like growth factor I receptor
|
| Swissprots |
Q05688
|
| Accessions |
AAB52601 DAA17722 Q05688 CV979948 CX952835 EE901083 EH174755 HQ703508 AEX15867 X54980 CAA38724 XM_010816884 XP_010815186 NM_001244612 NP_001231541
|
| Function |
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma
|
