| Gene Symbol |
TBP
|
| Entrez Gene |
6908
|
| Alt Symbol |
GTF2D, GTF2D1, HDL4, SCA17, TFIID
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TATA box binding protein
|
| Other Description |
TATA sequence-binding protein|TATA-box binding protein N-terminal domain|TATA-box factor|TATA-box-binding protein|transcription initiation factor TFIID TBP subunit
|
| Swissprots |
Q9UC02 Q6IBM6 Q16845 B4E3B3 F5H869 P20226
|
| Accessions |
AAQ75701 AAS18267 ACJ04969 ACJ04970 ACJ04971 ACJ04972 ACJ04973 ACJ04974 ACJ04975 ACJ04976 ACJ04977 ACJ04978 ACJ04979 ACJ04980 ACJ04981 EAW47418 EAW47419 P20226 AK298272 BAG60533 AK304648 BAG65425 AK315222 BC109053 AAI09054 BC109054 AAI09055 BC110341 AAI10342 BM720195 BT019657 AAV38463 CA422572 CR456776 CAG33057 EU831783 ACE87301 EU831861 ACE86620 EU832760 ACE87771 FJ770048 ACN86311 GQ129302 ACT64436 L37705 M34960 AAC03409 M55654 AAA36731 X54993 CAA38736 Z22828 NM_001172085 NP_001165556 NM_003194 NP_003185
|
| Function |
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. {ECO:0000269|PubMed:15970593}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Widely expressed, with levels highest in the testis and ovary. {ECO:0000269|PubMed:17570761}.
|
| Top Pathways |
Huntington's disease, HTLV-I infection, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection
|
![Western Blot: TATA binding protein TBP Overexpression Lysate (Adult Normal) [NBL1-16741] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TATA binding protein TBP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6854_TATA%2520binding%2520protein%2520TBP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16741-img0002.jpg)