| Gene Symbol | Il1b |
|---|---|
| Entrez Gene | 24494 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | interleukin 1 beta |
| Other Description | IL-1 beta|interleukin-1 beta |
| Swissprots | Q63264 |
| Accessions | EDL80163 Q63264 BC091141 AAH91141 M98820 AAA41426 NM_031512 NP_113700 |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Top Pathways | Tuberculosis, Salmonella infection, MAPK signaling pathway, Herpes simplex infection, Legionellosis |