| Gene Symbol |
Il1b
|
| Entrez Gene |
24494
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1 beta
|
| Other Description |
IL-1 beta|interleukin-1 beta
|
| Swissprots |
Q63264
|
| Accessions |
EDL80163 Q63264 BC091141 AAH91141 M98820 AAA41426 NM_031512 NP_113700
|
| Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
|
| Subcellular Location |
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
|
| Top Pathways |
Tuberculosis, Salmonella infection, MAPK signaling pathway, Herpes simplex infection, Legionellosis
|