Gene Symbol | GNMT |
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Entrez Gene | 27232 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | glycine N-methyltransferase |
Other Description | HEL-S-182mP|epididymis secretory sperm binding protein Li 182mP |
Swissprots | Q14749 Q9NS24 Q5T8W2 Q9NNZ1 |
Accessions | AAF78289 EAX04123 EAX04124 Q14749 AF101477 AAF78290 BC032627 AAH32627 DQ890819 ABM81745 DQ893974 ABM84900 FJ224320 ACI46012 HG499230 HG499231 X62250 CAA44164 XM_011514493 XP_011512795 XM_011514494 XP_011512796 NM_018960 NP_061833 |
Function | Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. {ECO:0000269|PubMed:15340920, ECO:0000269|PubMed:17660255}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Abundant in liver. |
Top Pathways | Glycine, serine and threonine metabolism |
GNMT CRISPR/Cas9 KO Plasmid (h) - sc-404941 from Santa Cruz Biotechnology
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GNMT HDR Plasmid (h) - sc-404941-HDR from Santa Cruz Biotechnology
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GNMT Double Nickase Plasmid (h) - sc-404941-NIC from Santa Cruz Biotechnology
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GNMT Double Nickase Plasmid (h2) - sc-404941-NIC-2 from Santa Cruz Biotechnology
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GNMT CRISPR Activation Plasmid (h) - sc-404941-ACT from Santa Cruz Biotechnology
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GNMT CRISPR Activation Plasmid (h2) - sc-404941-ACT-2 from Santa Cruz Biotechnology
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GNMT Lentiviral Activation Particles (h) - sc-404941-LAC from Santa Cruz Biotechnology
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GNMT Lentiviral Activation Particles (h2) - sc-404941-LAC-2 from Santa Cruz Biotechnology
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GNMT siRNA (h) - sc-62391 from Santa Cruz Biotechnology
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GNMT shRNA Plasmid (h) - sc-62391-SH from Santa Cruz Biotechnology
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GNMT shRNA (h) Lentiviral Particles - sc-62391-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9440 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9440 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00334 from Sigma-Aldrich
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GNMT siRNA (Human) - CRH9026 from Cohesion Biosciences
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GNMT - MBS8213466 from MyBioSource
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shRNA set against Human GNMT (NM_018960.4) - SHH305030 from Creative biogene
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shRNA set against Human GNMT(NM_018960.4) - SHH093305 from Creative biogene
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GNMT shRNA Plasmid (Human) - CHH9026 from Cohesion Biosciences
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GNMT miRNA 3'UTR clone - MiUTR1H-04122 from Creative biogene
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