| Gene Symbol |
TXNDC2
|
| Entrez Gene |
84203
|
| Alt Symbol |
SPTRX, SPTRX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thioredoxin domain containing 2 (spermatozoa)
|
| Other Description |
sperm-specific thioredoxin 1|spermatid-specific thioredoxin-1|sptrx-1|thioredoxin domain-containing 2 (spermatozoa)|thioredoxin domain-containing protein 2
|
| Swissprots |
Q8N7U4 A5YM73 Q96RX3 Q9H0L8 Q86VQ3
|
| Accessions |
CBH19491 EAX01593 EAX01594 Q86VQ3 AF080095 AAK94950 AK097656 BAC05133 AK303045 BAG64165 AL136742 CAB66676 BC050132 AAH50132 BI463874 BI831969 BM554364 DB032859 DB037693 EF560747 ABQ59057 EU832471 ACE87643 EU832550 ACE86952 NM_001098529 NP_001091999 NM_032243 NP_115619
|
| Function |
Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11399755}. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.
|
| Tissue Specificity |
Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids. {ECO:0000269|PubMed:11399755}.
|