Gene Symbol | FDXR |
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Entrez Gene | 2232 |
Alt Symbol | ADXR |
Species | Human |
Gene Type | protein-coding |
Description | ferredoxin reductase |
Other Description | AR|NADPH:adrenodoxin oxidoreductase, mitochondrial|adrenodoxin reductase|adrenodoxin-NADP(+) reductase|ferredoxin--NADP(+) reductase |
Swissprots | B4DHX5 Q9BU12 P22570 E7EQC1 Q13716 B4DQQ4 B7Z7G2 B4DDI7 Q4PJI0 B4DX24 |
Accessions | AAA51668 AAA51669 AAY68215 EAW89205 EAW89206 EAW89207 EAW89208 EAW89209 P22570 AK094120 BAG52818 AK098648 AK223530 BAD97250 AK293208 BAG56748 AK293210 BAG56750 AK295307 BAG58287 AK298908 BAG61016 AK301779 BAG63236 AK301977 BAH13598 AW590330 BC002960 AAH02960 BC011521 BC018911 BC034763 BC063493 AAH63493 BT006684 AAP35330 DA267443 J03826 AAB59497 XM_006721772 XP_006721835 XM_011524527 XP_011522829 XM_011524528 XP_011522830 XM_011524529 XP_011522831 XM_011524530 XP_011522832 XM_011524531 XP_011522833 XM_011524532 XP_011522834 XM_011524533 XP_011522835 NM_001258012 NP_001244941 NM_001258013 NP_001244942 NM_001258014 NP_001244943 NM_001258015 NP_001244944 NM_001258016 NP_001244945 NM_004110 NP_004101 NM_024417 NP_077728 NR_047576 |
Function | Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. |
Subcellular Location | Mitochondrion matrix. |
ADX Reductase CRISPR/Cas9 KO Plasmid (h) - sc-406069 from Santa Cruz Biotechnology
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ADX Reductase HDR Plasmid (h) - sc-406069-HDR from Santa Cruz Biotechnology
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ADX Reductase Double Nickase Plasmid (h) - sc-406069-NIC from Santa Cruz Biotechnology
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ADX Reductase Double Nickase Plasmid (h2) - sc-406069-NIC-2 from Santa Cruz Biotechnology
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ADX Reductase CRISPR Activation Plasmid (h) - sc-406069-ACT from Santa Cruz Biotechnology
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ADX Reductase CRISPR Activation Plasmid (h2) - sc-406069-ACT-2 from Santa Cruz Biotechnology
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ADX Reductase Lentiviral Activation Particles (h) - sc-406069-LAC from Santa Cruz Biotechnology
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ADX Reductase Lentiviral Activation Particles (h2) - sc-406069-LAC-2 from Santa Cruz Biotechnology
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ADX Reductase siRNA (h) - sc-61906 from Santa Cruz Biotechnology
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ADX Reductase shRNA Plasmid (h) - sc-61906-SH from Santa Cruz Biotechnology
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ADX Reductase shRNA (h) Lentiviral Particles - sc-61906-V from Santa Cruz Biotechnology
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Ferredoxin Reductase RNAi - H00002232-R01 from Novus Biologicals
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Ferredoxin Reductase RNAi - H00002232-R02 from Novus Biologicals
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Androgen R/NR3C4 RNAi - H00000367-R02 from Novus Biologicals
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MISSION® esiRNA - EHU034841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1135 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1134 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1134 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1135 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02166 from Sigma-Aldrich
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FDXR siRNA (Human) - CRH1557 from Cohesion Biosciences
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FDXR - MBS8236180 from MyBioSource
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shRNA set against Human FDXR (NM_004110.3) - SHH293977 from Creative biogene
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shRNA set against Human FDXR(NM_024417.2) - SHH055415 from Creative biogene
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shRNA set against Human FDXR(NM_004110.3) - SHH055433 from Creative biogene
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