Gene Symbol | KCNT2 |
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Entrez Gene | 343450 |
Alt Symbol | KCa4.2, SLICK, SLO2.1 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, sodium activated subfamily T, member 2 |
Other Description | potassium channel subfamily T member 2|potassium channel, subfamily T, member 2|sequence like an intermediate conductance potassium channel subunit|sodium and chloride-activated ATP-sensitive potassium channel Slo2.1|sodium-and chloride-activated ATP-sensitive potassium channel (SLICK) |
Swissprots | Q3SY59 Q5VTN1 Q6UVM3 Q6ZMT3 |
Accessions | CCA64132 EAW91255 EAW91256 Q6UVM3 AK127807 BAC87144 AK131498 BAD18642 AK309729 AY359444 AAR06170 BC103947 AAI03948 BC103948 AAI03949 BC103949 AAI03950 BC103950 AAI03951 BX647852 CAI46099 DA799907 EU251076 ABX11496 XM_006711294 XP_006711357 XM_006711295 XP_006711358 XM_006711297 XP_006711360 XM_011509482 XP_011507784 XM_011509483 XP_011507785 XR_921773 XR_921774 XR_921775 NM_001287819 NP_001274748 NM_001287820 NP_001274749 NM_198503 NP_940905 |
Function | Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. {ECO:0000250, ECO:0000269|PubMed:14684870, ECO:0000269|PubMed:16687497}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
KCNT2 CRISPR/Cas9 KO Plasmid (h) - sc-409097 from Santa Cruz Biotechnology
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KCNT2 HDR Plasmid (h) - sc-409097-HDR from Santa Cruz Biotechnology
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KCNT2 Double Nickase Plasmid (h) - sc-409097-NIC from Santa Cruz Biotechnology
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KCNT2 Double Nickase Plasmid (h2) - sc-409097-NIC-2 from Santa Cruz Biotechnology
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KCNT2 CRISPR Activation Plasmid (h) - sc-409097-ACT from Santa Cruz Biotechnology
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KCNT2 CRISPR Activation Plasmid (h2) - sc-409097-ACT-2 from Santa Cruz Biotechnology
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KCNT2 Lentiviral Activation Particles (h) - sc-409097-LAC from Santa Cruz Biotechnology
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KCNT2 Lentiviral Activation Particles (h2) - sc-409097-LAC-2 from Santa Cruz Biotechnology
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KCNT2 siRNA (h) - sc-88420 from Santa Cruz Biotechnology
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KCNT2 shRNA Plasmid (h) - sc-88420-SH from Santa Cruz Biotechnology
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KCNT2 shRNA (h) Lentiviral Particles - sc-88420-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU048651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10995 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10995 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11376 from Sigma-Aldrich
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KCNT2 siRNA (Human) - CRJ7432 from Cohesion Biosciences
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KCNT2 RNAi - H00343450-R01 from Novus Biologicals
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shRNA set against Human KCNT2 (NM_198503.2) - SHH323763 from Creative biogene
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shRNA set against Human KCNT2(NM_198503.2) - SHL192720 from Creative biogene
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Human KCNT2 siRNA - orb277933 from Biorbyt
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KCNT2 shRNA Plasmid (Human) - CHJ7432 from Cohesion Biosciences
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KCNT2 miRNA 3'UTR clone - MiUTR1H-05170 from Creative biogene
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