INTS6
| Gene Symbol | INTS6 |
|---|---|
| Entrez Gene | 26512 |
| Alt Symbol | DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrator complex subunit 6 |
| Other Description | DEAD box protein|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26|RNA helicase HDB|protein deleted in cancer 1 |
| Swissprots | Q9Y5M9 Q9UFK0 Q6PJP4 Q9UL03 Q0P664 |
| Accessions | CAC07726 CAF86852 EAX08873 EAX08874 EAX08875 EAX08876 EAX08877 EAX08878 EAX08879 EAX08880 EAX08881 Q9UL03 AA251444 AA262171 AF086440 AF097645 AAF03046 AF141326 AAD39481 AK074946 BAG52037 AK096696 BAG53352 AK128795 BAG54738 AK296801 BAG59375 AK303869 BAG64807 AK304218 BAG65090 AL117626 CAB56020 AL833524 AW967611 BC013358 AAH13358 BC018725 AAH18725 BC032386 AAH32386 BC039829 AAH39829 BC040581 BC094745 BE160101 BG621629 BK005730 DAA05730 BM699545 BU754174 BX116410 DA182797 FN136361 XM_005266340 XP_005266397 XM_005266341 XP_005266398 XM_011535040 XP_011533342 XM_011535041 XP_011533343 NM_001039937 NP_001035026 NM_001039938 NP_001035027 NM_001306091 NP_001293020 NM_012141 NP_036273 |
| Function | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11939413}. |
| Tissue Specificity | Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10467397}. |
DICE1 CRISPR/Cas9 KO Plasmid (h) - sc-409255 from Santa Cruz Biotechnology
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DICE1 HDR Plasmid (h) - sc-409255-HDR from Santa Cruz Biotechnology
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DICE1 Double Nickase Plasmid (h) - sc-409255-NIC from Santa Cruz Biotechnology
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DICE1 Double Nickase Plasmid (h2) - sc-409255-NIC-2 from Santa Cruz Biotechnology
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DICE1 CRISPR Activation Plasmid (h) - sc-409255-ACT from Santa Cruz Biotechnology
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DICE1 CRISPR Activation Plasmid (h2) - sc-409255-ACT-2 from Santa Cruz Biotechnology
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DICE1 Lentiviral Activation Particles (h) - sc-409255-LAC from Santa Cruz Biotechnology
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DICE1 Lentiviral Activation Particles (h2) - sc-409255-LAC-2 from Santa Cruz Biotechnology
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DICE1 siRNA (h) - sc-45802 from Santa Cruz Biotechnology
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DICE1 shRNA Plasmid (h) - sc-45802-SH from Santa Cruz Biotechnology
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DICE1 shRNA (h) Lentiviral Particles - sc-45802-V from Santa Cruz Biotechnology
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INTS6 RNAi - H00026512-R02 from Novus Biologicals
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MISSION® esiRNA - EHU131311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10718 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10718 from Sigma-Aldrich
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INTS6 siRNA (Human) - CRH8841 from Cohesion Biosciences
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INTS6 - MBS8215978 from MyBioSource
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shRNA set against Human Ints6 (NM_012141.2) - SHH320017 from Creative biogene
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shRNA set against Human INTS6(NM_001039938.1) - SHG222481 from Creative biogene
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shRNA set against Human INTS6(NM_012141.2) - SHG222631 from Creative biogene
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shRNA set against Human INTS6(NM_001039937.1) - SHG222649 from Creative biogene
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shRNA set against Human INTS6(NM_001039938.1) - SHG222721 from Creative biogene
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INTS6 shRNA Plasmid (Human) - CHH8841 from Cohesion Biosciences
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INTS6 miRNA 3'UTR clone - MiUTR1H-04973 from Creative biogene
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INTS6 miRNA 3'UTR clone - MiUTR1H-04974 from Creative biogene
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