| Gene Symbol | CCNT1 |
|---|---|
| Entrez Gene | 904 |
| Alt Symbol | CCNT, CYCT1, HIVE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin T1 |
| Other Description | CDK9-associated C-type protein|cyclin C-related protein|cyclin-T1|human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1 |
| Swissprots | O60581 O60563 A9XU13 E7EX76 |
| Accessions | AAF72184 EAW57998 O60563 AF045161 AAC39638 AF048730 AAC39664 AK002085 AK290990 BAF83679 AL832083 BC156506 AAI56507 BC172543 AAI72543 BX098766 BX537514 BX537516 EF688064 ABV58572 HY016640 NM_001240 NP_001231 NM_001277842 NP_001264771 |
| Function | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12944466}. |
| Tissue Specificity | Ubiquitously expressed. |
| Top Pathways | Transcriptional misregulation in cancer |