CCNT1

Gene Symbol CCNT1
Entrez Gene 904
Alt Symbol CCNT, CYCT1, HIVE1
Species Human
Gene Type protein-coding
Description cyclin T1
Other Description CDK9-associated C-type protein|cyclin C-related protein|cyclin-T1|human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
Swissprots O60581 O60563 A9XU13 E7EX76
Accessions AAF72184 EAW57998 O60563 AF045161 AAC39638 AF048730 AAC39664 AK002085 AK290990 BAF83679 AL832083 BC156506 AAI56507 BC172543 AAI72543 BX098766 BX537514 BX537516 EF688064 ABV58572 HY016640 NM_001240 NP_001231 NM_001277842 NP_001264771
Function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12944466}.
Tissue Specificity Ubiquitously expressed.
Top Pathways Transcriptional misregulation in cancer

Cyclin T1 Antibody - 8744 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Cyclin T1 Antibody.

cyclin T1 (E-3) - sc-271348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin T1 (E-3): sc-271348. Western blot analysis of cyclin T1 expression in K-562 (A) and Jurkat (B) nuclear extracts.

cyclin T1 (E-7) - sc-398695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin T1 (E-7): sc-398695. Western blot analysis of cyclin T1 expression in HeLa whole cell lysate.

cyclin T1 (H-245) - sc-10750 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin T1 (H-245): sc-10750. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

cyclin T1 (T-18) - sc-8127 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cyclin T1 (T-18): sc-8127. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymph node showing nuclear localization.

cyclin T1 (E-6) - sc-271576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin T1 (E-6): sc-271576. Western blot analysis of cyclin T1 expression in K-562 nuclear extract.

cyclin T1 (N-19) - sc-8126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cyclin T1 (N-19): sc-8126. Western blot analysis of cyclin T1 expression in A-431 nuclear extract.

cyclin T1 (C-20) - sc-8128 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cyclin T1 (C-20): sc-8128. Immunofluorescence staining of methanol-fixed Y79 cells showing nuclear localization.

cyclin T1 (C-6) - sc-271575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin T1 (C-6): sc-271575. Western blot analysis of cyclin T1 expression in K-562 nuclear extract.

Anti-Cyclin T1 antibody - ab2098 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab2098 (2µg/ml) staining Cyclin T1 in human lymph node using an automated system (DAKO Autostainer Plus). Using this protocol there is strong nuclear staining.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer citrate pH6.1 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-Cyclin T1 antibody - ab27963 from Abcam

Prices $378.00
Sizes 200 µl
Host Sheep
Clonality Polyclonal
All lanes : Anti-Cyclin T1 antibody (ab27963) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HeLa cell nuclear lysateLane 3 : monkey Vero cell lysateLane 4 : mouse kidney cell lysateLane 5 : Drosophila S2 cell lysateLane 6 : horse dermal cell lysateSecondarydonkey anti-sheep peroxidase conjugate at 1/20000 dilution

Anti-Cyclin T1 antibody - ab176702 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin T1 antibody (ab176702) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µg

Anti-Cyclin T1 antibody - ab106968 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Cyclin T1 antibody (ab106968) at 1/100 dilution + MCF-7 cell line lysate at 35 µg

Anti-Cyclin T1 antibody - ab83314 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa425-475) - LS-C290169 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Cyclin T1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-Cyclin T1 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285, AP) - LS-C253775 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285, APC) - LS-C253776 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285, Biotin) - LS-C253777 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285, Azide-free, HRP) - LS-C253780 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285, FITC) - LS-C253778 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285, PE) - LS-C253783 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (N-Terminus) - LS-C102825 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCNT1 / Cyclin T1 antibody LS-C102825 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-CCNT1 / Cyclin T1 Antibody (aa256-285) - LS-C320127 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody - LS-C306790 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CCNT1 / Cyclin T1 Antibody (aa250-300) - LS-C290164 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Cyclin T1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-Cyclin T1 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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