CCNT1

Gene Symbol CCNT1
Entrez Gene 904
Alt Symbol CCNT, CYCT1, HIVE1
Species Human
Gene Type protein-coding
Description cyclin T1
Other Description CDK9-associated C-type protein|cyclin C-related protein|cyclin-T1|human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
Swissprots O60581 O60563 A9XU13 E7EX76
Accessions AAF72184 EAW57998 O60563 AF045161 AAC39638 AF048730 AAC39664 AK002085 AK290990 BAF83679 AL832083 BC156506 AAI56507 BC172543 AAI72543 BX098766 BX537514 BX537516 EF688064 ABV58572 HY016640 NM_001240 NP_001231 NM_001277842 NP_001264771
Function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12944466}.
Tissue Specificity Ubiquitously expressed.
Top Pathways Transcriptional misregulation in cancer

Human Cyclin T1 protein fragment - ab152261 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE stained with Coomassie Blue.

CCNT1 / Cyclin T1 Antibody Blocking Peptide - LS-E391 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CCNT1 / Cyclin T1 Antibody Blocking Peptide - LS-E10508 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CCNT1 / Cyclin T1 Antibody Blocking Peptide - LS-E31395 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

CCNT1-Antibody-Center-Blocking-peptide - BP10669c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CCNT1 Blocking Peptide - 33R-2426 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Cyclin T1 - H00000904-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Cyclin T1 - H00000904-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CCNT1 Peptide - 7223P from ProSci

Category Peptide
Species Human
Western blot analysis of CCNT1 in rat brain tissue lysate with CCNT1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Recombinant Human Cyclin-T1(CCNT1) - CSB-YP004832HU CSB-EP004832HU CSB-BP004832HU CSB-MP004832HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant Human Cyclin T1 Protein - H00000904-Q01 from Novus Biologicals

Category Protein
Prices $305.00, $445.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CCNT1 Peptide, Human - M34GP02664H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Cyclin-T1 (CCNT1), Recombinant Protein - MBS1225669 from MyBioSource

Category Protein
Prices $1,535.00, $1,535.00, $1,765.00, $1,765.00, $2,635.00, $2,635.00, $3,080.00, $3,080.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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