KCNAB1

Gene Symbol	KCNAB1
Entrez Gene	7881
Alt Symbol	AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated subfamily A regulatory beta subunit 1
Other Description	K(+) channel subunit beta-1\|K+ channel Beta1a chain\|potassium channel beta 3 chain\|potassium channel beta3 subunit\|potassium channel shaker chain beta 1a\|potassium voltage-gated channel beta subunit\|potassium voltage-gated channel, shaker-related subfamily, beta member 1\|voltage-gated potassium channel beta-1 subunit\|voltage-gated potassium channel subunit beta-1
Swissprots	Q6PI60 B3KPZ4 Q14722 Q13031 A8K9H8 Q13302 Q99869 A8KAD4 Q16547
Accessions	EAW78732 EAW78733 EAW78734 EAW78735 EAW78736 Q14722 AI344124 AK057059 BAG51856 AK127240 BAG54461 AK292693 BAF85382 AK292999 BAF85688 AK296728 BAH12421 AK303287 BAH13931 AU076410 AY780786 AAV98356 BC043166 AAH43166 BQ721076 DA331209 DA408045 DC410397 HQ448541 ADQ33020 L39833 AAC37573 L47665 AAC41926 U16953 AAC50122 U17968 AAC50113 U33428 AAC50953 XM_005247753 XP_005247810 XM_005247754 XP_005247811 XM_011513115 XP_011511417 XM_011513116 XP_011511418 XM_011513117 XP_011511419 NM_001308217 NP_001295146 NM_001308222 NP_001295151 NM_003471 NP_003462 NM_172159 NP_751891 NM_172160 NP_751892
Function	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels fo
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:17540341}. Membrane {ECO:0000250\|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269\|PubMed:17540341}; Peripheral membrane protein {ECO:0000269\|PubMed:17540341}; Cytoplasmic side {ECO:0000269\|PubMed:17540341}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000269\|PubMed:17540341}.
Tissue Specificity	In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. {ECO:0000269\|PubMed:7603988, ECO:0000269\|PubMed:8938711}.

KVβ.1 (K-13) - sc-51105 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KVβ.1 (C-13) - sc-51104 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KVβ.1 (Q-13) - sc-51106 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KVβ.1 (Q-13): sc-51106. Western blot analysis of KVβ.1 expression in non-transfected: sc-117752 (A) and mouse KVβ.1 transfected: sc-121258 (B) 293T whole cell lysates.

Anti-Kv beta 1 antibody - ab86202 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-Kv beta 1 antibody [4E7] - ab119781 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4E7

All lanes : Anti-Kv beta 1 antibody [4E7] (ab119781) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Kv beta 1 cDNALysates/proteins at 5 µg per lane.

Anti-Kv beta 1 antibody [S40-17] - ab99012 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S40-17

Image from David M et al., J Biol Chem. 2012 Jun 15;287(25):21416-28. Epub 2012 Apr 30.Fig 10.; doi: 10.1074/jbc.M111.328278; June 15, 2012, The Journal of Biological Chemistry, 287, 21416-21428.

Anti-Kv beta 1 antibody - N-terminal - ab174508 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Kv beta 1 antibody - N-terminal (ab174508) at 1/100 dilution + MDA-MB453 cell lysate at 35 µg

Anti-KCNAB1 Antibody (clone 4E7) - LS-C173548 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4E7

IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-KCNAB1 mouse monoclonal antibody.

Anti-KCNAB1 Antibody (clone 7C7) - LS-C173550 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	7C7

IHC of paraffin-embedded Human pancreas tissue using anti-KCNAB1 mouse monoclonal antibody.

Anti-KCNAB1 Antibody (clone 7F12) - LS-C337560 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	7F12

IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-KCNAB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-KCNAB1 Antibody (aa311-360) - LS-C19307 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 390) - LS-C227908 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (clone S40-17) - LS-C150413 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S40-17

IHC analysis of Pan-Kv Beta in frozen sections of mouse brain extract using KCNAB1 antibody.

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 488) - LS-C227909 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 565) - LS-C227910 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (clone S9-40) - LS-C150460 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	S9-40

IHC analysis of KvBeta1.1 tested on mouse brain using KCNAB1 antibody.. Granular staining of the cytoplasm of neurons. The rest of the cells are negative.

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 594) - LS-C227911 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 633) - LS-C227912 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (clone 2A8) - LS-C173547 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2A8

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNAB1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNAB1.

Anti-KCNAB1 Antibody (clone 9C9) - LS-C173546 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	9C9

Anti-KCNAB1 Antibody (clone 6E5) - LS-C173551 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6E5

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 680) - LS-C227914 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 655) - LS-C227913 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, Atto 700) - LS-C227915 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

Anti-KCNAB1 Antibody (aa7-28, clone S9-40, AP) - LS-C227916 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	S9-40

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