| Gene Symbol | KCNAB1 |
|---|---|
| Entrez Gene | 7881 |
| Alt Symbol | AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated subfamily A regulatory beta subunit 1 |
| Other Description | K(+) channel subunit beta-1|K+ channel Beta1a chain|potassium channel beta 3 chain|potassium channel beta3 subunit|potassium channel shaker chain beta 1a|potassium voltage-gated channel beta subunit|potassium voltage-gated channel, shaker-related subfamily, beta member 1|voltage-gated potassium channel beta-1 subunit|voltage-gated potassium channel subunit beta-1 |
| Swissprots | Q6PI60 B3KPZ4 Q14722 Q13031 A8K9H8 Q13302 Q99869 A8KAD4 Q16547 |
| Accessions | EAW78732 EAW78733 EAW78734 EAW78735 EAW78736 Q14722 AI344124 AK057059 BAG51856 AK127240 BAG54461 AK292693 BAF85382 AK292999 BAF85688 AK296728 BAH12421 AK303287 BAH13931 AU076410 AY780786 AAV98356 BC043166 AAH43166 BQ721076 DA331209 DA408045 DC410397 HQ448541 ADQ33020 L39833 AAC37573 L47665 AAC41926 U16953 AAC50122 U17968 AAC50113 U33428 AAC50953 XM_005247753 XP_005247810 XM_005247754 XP_005247811 XM_011513115 XP_011511417 XM_011513116 XP_011511418 XM_011513117 XP_011511419 NM_001308217 NP_001295146 NM_001308222 NP_001295151 NM_003471 NP_003462 NM_172159 NP_751891 NM_172160 NP_751892 |
| Function | Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels fo |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17540341}. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17540341}; Peripheral membrane protein {ECO:0000269|PubMed:17540341}; Cytoplasmic side {ECO:0000269|PubMed:17540341}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000269|PubMed:17540341}. |
| Tissue Specificity | In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. {ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:8938711}. |