COPZ1

Gene Symbol COPZ1
Entrez Gene 22818
Alt Symbol CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP
Species Human
Gene Type protein-coding
Description coatomer protein complex, subunit zeta 1
Other Description coatomer subunit zeta-1|zeta-1 COP|zeta-1-coat protein
Swissprots Q549N6 Q9Y3C3 F8VWL5 F8VS17 B4DDX8 B4DHZ0 P61923
Accessions CCO13713 EAW96774 EAW96775 P61923 AB047848 BAB17659 AF086911 AAP97141 AF151878 AAD34115 AF161529 AAF29144 AK025956 AK026190 AK223188 BAD96908 AK293377 BAG56889 AK295325 BAG58302 AK311027 BC002849 AAH02849 CA431603 CB127540 DA562746 HQ448364 ADQ32844 XM_011538029 XP_011536331 NM_001271734 NP_001258663 NM_001271735 NP_001258664 NM_001271736 NP_001258665 NM_016057 NP_057141 NR_073424
Function The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

COPZ1 (B-12) - sc-398081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPZ1 (B-12): sc-398081. Western blot analysis of COPZ1 expression in COS (A), K-562 (B) and Jurkat (C) whole cell lysates and human brain tissue extract (D).

COPZ1 (H-12) - sc-398219 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPZ1 (H-12): sc-398219. Western blot analysis of COPZ1 expression in COS (A), K-562 (B) and Jurkat (C) whole cell lysates.

COPZ1 (F-11) - sc-398220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPZ1 (F-11): sc-398220. Western blot analysis of COPZ1 expression in COS (A), K-562 (B) and Jurkat (C) whole cell lysates.

COPZ1/2 (L-13) - sc-13348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

COPZ1 (D-20) - sc-13349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
COPZ1 (D-20): sc-13349. Western blot analysis of COPZ1 expression in K-562 whole cell lysate.

Anti-COPZ1 antibody - ab178974 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-COPZ1 antibody (ab178974) at 1 µg/ml + COLO205 whole cell lysate at 10 µg

Anti-COPZ1 antibody - ab74370 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab74370 at 1/50 dilution staining COPZ1 in human cervix carcinoma by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-COPZ1 Antibody (aa23-53, Biotin) - LS-C208560 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa23-53, AP) - LS-C208558 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa23-53, Azide-free, HRP) - LS-C208561 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa23-53, PE) - LS-C208563 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa23-53, APC) - LS-C208559 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa23-53, FITC) - LS-C208562 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa23-53) - LS-C320528 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (N-Terminus) - LS-C186940 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Human COLO205. COPZ1 antibody dilution 1.0 ug/ml.

Anti-COPZ1 Antibody (C-Terminus) - LS-C170814 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPZ1 Antibody (aa11-60) - LS-C119865 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human cervix carcinoma tissue, using COPZ1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-COPZ1 Antibody - LS-C332529 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using COPZ1 antibody.

Anti-COPZ1 Antibody (Ile48) - LS-C177448 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
IHC of COP 1 (I48) pAb in paraffin-embedded human cervix carcinoma tissue.

Anti-COPZ1 Antibody (aa23-53) - LS-C159394 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPZ1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The COPZ1 antibody detected the COPZ1 protein (arrow).

COPZ1 Antibody - NBP1-00762 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: COPZ1 Antibody [NBP1-00762] - Western blot (WB) analysis of COPZ1 (I48) antibody in extracts from Jurkat cells

COPZ1 Antibody - NBP2-13858 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: COPZ1 Antibody [NBP2-13858] Staining of human cerebellum shows strong nuclear positivity in Purkinje cells.

COPZ1 Antibody - H00022818-B01 from Novus Biologicals

Host Mouse
Clonality Polyclonal
Western Blot: COPZ1 Antibody [H00022818-B01] - analysis of COPZ1 expression in transfected 293T cell line by COPZ1 MaxPab polyclonal antibody (B01). Lane 1: COPZ1 transfected lysate (20.20 KDa). Lane 2: Non-transfected lysate.

Anti-COPZ1 (46-60) antibody produced in rabbit - SAB1101759 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-COPZ1 (46-60) (RB): <B>Cat. No. SAB1101759</B>: Immunofluorescence of HUVEC cells using Anti-COPZ1 (46-60) (RB) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-COPZ1 (31-45) antibody produced in rabbit - SAB1101758 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-COPZ1 (31-45) (RB): <B>Cat. No. SAB1101758</B>: Immunofluorescence of HUVEC cells using Anti-COPZ1 (31-45) (RB) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com
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