| Gene Symbol | COPZ1 |
|---|---|
| Entrez Gene | 22818 |
| Alt Symbol | CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP |
| Species | Human |
| Gene Type | protein-coding |
| Description | coatomer protein complex, subunit zeta 1 |
| Other Description | coatomer subunit zeta-1|zeta-1 COP|zeta-1-coat protein |
| Swissprots | Q549N6 Q9Y3C3 F8VWL5 F8VS17 B4DDX8 B4DHZ0 P61923 |
| Accessions | CCO13713 EAW96774 EAW96775 P61923 AB047848 BAB17659 AF086911 AAP97141 AF151878 AAD34115 AF161529 AAF29144 AK025956 AK026190 AK223188 BAD96908 AK293377 BAG56889 AK295325 BAG58302 AK311027 BC002849 AAH02849 CA431603 CB127540 DA562746 HQ448364 ADQ32844 XM_011538029 XP_011536331 NM_001271734 NP_001258663 NM_001271735 NP_001258664 NM_001271736 NP_001258665 NM_016057 NP_057141 NR_073424 |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}. |