NLRP3

Gene Symbol	NLRP3
Entrez Gene	114548
Alt Symbol	AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1
Species	Human
Gene Type	protein-coding
Description	NLR family, pyrin domain containing 3
Other Description	NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3|NACHT, LRR and PYD containing protein 3|NACHT, LRR and PYD domains-containing protein 3|PYRIN-containing APAF1-like protein 1|caterpiller protein 1.1|cold autoinflammatory syndrome 1 protein|cryopyrin|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
Swissprots	B2RC97 Q96P20 B7ZKT3 O75434 B7ZKS9 Q8TEU9 Q17RS2 B7ZKT2 Q6TG35 Q8TCW0 Q59H68 Q5JQS8 Q8WXH9 Q5JQS9
Accessions	AAL12497 AAL12498 BAD51451 BAD51452 BAD51453 BAD51454 EAW77183 EAW77184 EAW77185 EAW77186 EAW77187 Q96P20 AB208891 BAD92128 AF054176 AAC39910 AF410477 AAL33908 AF418985 AAL14640 AF420469 AAL65136 AF427617 AAL33911 AF468522 AAL78632 AK027194 AK314998 BAG37494 AL601856 AY092033 AAM14669 AY422168 AAQ98889 BC117211 AAI17212 BC143359 AAI43360 BC143362 AAI43363 BC143363 AAI43364 DA244290 XM_005273036 XP_005273093 XM_005273037 XP_005273094 XM_011544048 XP_011542350 XM_011544049 XP_011542351 XM_011544050 XP_011542352 XM_011544051 XP_011542353 XM_011544052 XP_011542354 XM_011544053 XP_011542355 XM_011544054 XP_011542356 XM_011544055 XP_011542357 NM_001079821 NP_001073289 NM_001127461 NP_001120933 NM_001127462 NP_001120934 NM_001243133 NP_001230062 NM_004895 NP_004886 NM_183395 NP_899632
Function	May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. {ECO:0000269|PubMed:11786556, ECO:0000269|PubMed:14662828}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11786556, ECO:0000269|PubMed:14662828, ECO:0000269|PubMed:17164409}.
Tissue Specificity	Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. {ECO:0000269|PubMed:11786556, ECO:0000269|PubMed:12032915, ECO:0000269|PubMed:17164409, ECO:0000269|PubMed:17907925}.
Top Pathways	NOD-like receptor signaling pathway, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NACHT, LRR and PYD domains-containing protein 3 (NLRP3/C1orf7/CIAS1/NALP3/PYPAF1), Human, ELISA Kit - CSB-E15885h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

NACHT, LRR and PYD domains-containing protein 3, NLRP3, Human, ELISA Kit - E14531h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

NLR family, pyrin domain containing 3, ELISA Kit - MBS917009 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.039 ng/ml. Range 0.156 ng/ml - 10 ng/ml.

Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3/C1orf7/CIAS1/NALP3/PYPAF1) ELISA kit - CSB-E15885h from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Human NALP3 / NLRP3 ELISA Kit (Sandwich ELISA) - LS-F17337 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Bovine NALP3 / NLRP3 ELISA Kit (Custom ELISA) - LS-F17338 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse NALP3 / NLRP3 ELISA Kit (Sandwich ELISA) - LS-F17336 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

CLIA Kit for NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) - SCK115Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 27.5pg/mL. Range 68.59-50000pg/mL The standard curve concentrations used for the CLIA’s were 50000pg/mL, 16666.67pg/mL, 5555.56pg/mL, 1851.85pg/mL, 617.28pg/mL, 205.76pg/mL, 68.59pg/mL

NLRP3 - EKH8404 from Nordic BioSite Sensitivity 9.4pg/ml Range 15.6-1000pg/ml

Human NLRP3 ELISA Kit - E026668 from Biobool Category ELISA Kit Sensitivity 0.039 ng/ml

NLRP3 ELISA Kit (Human) (OKEH03368) - OKEH03368 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.312 - 20 ng/mL

Human NACHT, LRR and PYD domains-containing protein 3 ELISA Kit - EK3426 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.31 ng/mL -20.0 ng/mL

anti-NALP3 / Cryopyrin antibody - ARG55185 from Arigo Biolaboratories Category ELISA Kit

anti-NALP3 / Cryopyrin antibody - ARG64004 from Arigo Biolaboratories Category ELISA Kit

NACHT, LRR and PYD domains-containing protein 3, ELISA Kit - MBS2881831 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NACHT, LRR and PYD domains-containing protein 3, ELISA Kit - MBS9427260 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.31 ng/mL-20.0 ng/mL

NLR Family, Pyrin Domain Containing Protein 3 (NLRP3) , ELISA Kit - MBS2088206 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.117ng/mL Range 0.312-20ng/mL

NLRP3 (Nod Like Receptor Pyrins-3), ELISA Kit - MBS766141 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/ml Range 0.781-50ng/ml

NACHT, LRR and PYD domains-containing protein 3, ELISA Kit - MBS285414 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NLR Family, Pyrin Domain Containing Protein 3, CLIA Kit - MBS2031948 from MyBioSource Category CLIA Kit Prices $440.00, $655.00, $900.00, $3,705.00, $6,680.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 27.5pg/mL. Range 68.6-50,000pg/mL. The standard curve concentrations used for the CLIA's were 50,000pg/mL, 16,666.7pg/mL, 5,555.6pg/mL, 1,851.9pg/mL, 617.3pg/mL, 205.8pg/mL, 68.6pg/mL.

NLRP3 Chemi-Luminescent ELISA Kit (Human) (OKCD03830) - OKCD03830 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.0686 ng/mL Range 0.0686 - 50 ng/mL

Human NALP3 / NLRP3 ELISA Kit (Sandwich ELISA) - LS-F39626 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.117 Range 0.156-10 ng/ml

Rat NALP3 / NLRP3 ELISA Kit (Sandwich ELISA) - LS-F39627 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.112 Range 0.156-10 ng/ml

Human NALP3 / NLRP3 ELISA Kit (CLIA) - LS-F38859 from LifeSpan Bioscience Category ELISA Kit Sensitivity 27.5 Range 0.156-10 ng/ml

Human NALP3 / NLRP3 ELISA Kit (Sandwich ELISA) - LS-F31954 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.469 Range 0.156-10 ng/ml

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