TRPM1

Gene Symbol	TRPM1
Entrez Gene	4308
Alt Symbol	CSNB1C, LTRPC1, MLSN1
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily M, member 1
Other Description	long transient receptor potential channel 1\|melastatin-1\|transient receptor potential cation channel subfamily M member 1\|transient receptor potential melastatin family
Swissprots	Q6PE48 D9IDV3 H0YN37 Q7Z4N2 Q7Z4N4 O75560 Q7Z4N5 F8W865 Q7Z4N1 Q7Z4N3 D9IDV2
Accessions	EAW61260 EAW61261 EAW61262 EAW61263 EAW61264 Q7Z4N2 AB115498 BAC80200 AB115499 BAC80201 AB115500 BAC80202 AB115501 BAC80203 AB115502 BAC80204 AF071787 AAC80000 BC005892 BC017849 BC033627 BC058286 AAH58286 BC070356 BC156069 AAI56070 BM695497 BU741333 BU743036 BU933033 GQ502181 ACV53832 GU576175 HM135790 ADJ52077 HM135791 ADJ52078 N42519 XM_011547403 XP_011545705 XM_011547404 XP_011545706 XM_011547405 XP_011545707 XM_011547406 XP_011545708 XM_011548919 XP_011547221 XM_011548920 XP_011547222 XM_011548921 XP_011547223 XM_011548922 XP_011547224 NM_001252020 NP_001238949 NM_001252024 NP_001238953 NM_001252030 NP_001238959 NM_002420 NP_002411
Function	Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO:0000250, ECO:0000269\|PubMed:11535825, ECO:0000269\|PubMed:19878917, ECO:0000269\|PubMed:19896109}.
Subcellular Location	Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255, ECO:0000269\|PubMed:11535825}.
Tissue Specificity	Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. {ECO:0000269\|PubMed:11112417, ECO:0000269\|PubMed:19896109, ECO:0000269\|PubMed:9537257}.

MLSN1 (E-20) - sc-16999 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-TRPM1 antibody - ab72154 from Abcam

Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab72154 stained MALME-3M cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab72154 at 1/200 dilution overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-TRPM1 antibody - ab63019 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-TRPM1 antibody - ab63122 from Abcam

Host	Sheep
Clonality	Polyclonal

Anti-TRPM1 antibody - ab74851 from Abcam

Host	Rabbit
Clonality	Polyclonal

TRPM1 Antibody - NBP1-81284 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: TRPM1 Antibody [NBP1-81284] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & cytoplasm.

TRPM1 Antibody - NB110-74963 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRPM1 antibody produced in rabbit - HPA014785 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-TRPM1: <B>Cat. No. HPA014785</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon shows strong cytoplasmic and membranous positivity in glandular cells.

Anti-TRPM1 antibody produced in rabbit - SAB4301014 from Sigma-Aldrich

Prices	$230.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Human-TRPM1-Antibody - AG1450 from Abgent, a WuXi AppTec company

Prices	$375.00, $475.00, $575.00
Sizes	25 µl, 50 µl, 200 µl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of A875 (human melanoma cell line) lysate: 1. Anti-Human TRPM1 antibody (#AG1450), (1:200). 2. Anti-Human TRPM1 antibody, preincubated with the control peptide antigen.

TRPM1 / LTRPC1 antibody - 55111-1-AP from Acris Antibodies

Prices	$270.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

Immunofluorescent analysis of SH-SY5Y cells using 55111-1-AP( TRPM1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG

TRPM1 / LTRPC1 (C-term) antibody - AP32749PU-N from Acris Antibodies

Prices	$390.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Western blotting of Human A875 cell lysate using TRPM1 Antibody Cat.-No AM32781PU-N at 1/200 dilution (Lane 1) and preincubated with the control peptide antigen (Lane 2).

TRPM1 antibody - 55111-1-AP from Proteintech Group

Prices	$279.00
Sizes	con: 72 μg/150μl
Host	Rabbit
Clonality	Polyclonal

TRPM1 Antibody - 36874 from Signalway Antibody

Prices	$279.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #36874 at dilution 1/20.

TRPM1 Polyclonal Antibody - ESAP12620 from Elabscience

Prices	$296.00, $485.00
Sizes	120 μl, 200 μl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of Human brain using TRPM1 Polyclonal Antibody at dilution of 1:20

TRPM1 Polyclonal Antibody - ESAP15967 from Elabscience

Prices	$296.00, $485.00
Sizes	120 μl, 200 μl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of Human lung cancer using TRPM1 Polyclonal Antibody at dilution of 1:30

Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) - MAC812Hu22 from Uscn Life Science Inc.

Host	Mouse
Clonality	Monoclonal

Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 1 (TRPM1) - PAC812Hu01 from Uscn Life Science Inc.

Host	Rabbit
Clonality	Polyclonal

TRPM1 Antibody - OSR00187W from Thermo Fisher Scientific

Prices	$292.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

TRPM1 Antibody - OST00038W from Thermo Fisher Scientific

Prices	$292.00
Sizes	100 µl
Host	Sheep
Clonality	Polyclonal

TRPM1 Polyclonal Antibody - OST00109W from Thermo Fisher Scientific

Prices	$309.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

TRPM1 Polyclonal Antibody - OST00141W from Thermo Fisher Scientific

Prices	$309.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

TRPM1, Polyclonal Antibody - MBS2523675 from MyBioSource

Prices	$110.00, $150.00, $225.00, $360.00
Sizes	20 Âµl, 60 Âµl, 120 Âµl, 200 Âµl
Host	Rabbit
Clonality	Polyclonal

TRPM1, Polyclonal Antibody - MBS2522325 from MyBioSource

Prices	$110.00, $150.00, $225.00, $360.00
Sizes	20 Âµl, 60 Âµl, 120 Âµl, 200 Âµl
Host	Rabbit
Clonality	Polyclonal

Anti-TRPM1 Antibody - AB15560-50UL from EMD Millipore

Prices	$309.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

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