| Gene Symbol |
TRPM1
|
| Entrez Gene |
4308
|
| Alt Symbol |
CSNB1C, LTRPC1, MLSN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 1
|
| Other Description |
long transient receptor potential channel 1|melastatin-1|transient receptor potential cation channel subfamily M member 1|transient receptor potential melastatin family
|
| Swissprots |
Q6PE48 D9IDV3 H0YN37 Q7Z4N2 Q7Z4N4 O75560 Q7Z4N5 F8W865 Q7Z4N1 Q7Z4N3 D9IDV2
|
| Accessions |
EAW61260 EAW61261 EAW61262 EAW61263 EAW61264 Q7Z4N2 AB115498 BAC80200 AB115499 BAC80201 AB115500 BAC80202 AB115501 BAC80203 AB115502 BAC80204 AF071787 AAC80000 BC005892 BC017849 BC033627 BC058286 AAH58286 BC070356 BC156069 AAI56070 BM695497 BU741333 BU743036 BU933033 GQ502181 ACV53832 GU576175 HM135790 ADJ52077 HM135791 ADJ52078 N42519 XM_011547403 XP_011545705 XM_011547404 XP_011545706 XM_011547405 XP_011545707 XM_011547406 XP_011545708 XM_011548919 XP_011547221 XM_011548920 XP_011547222 XM_011548921 XP_011547223 XM_011548922 XP_011547224 NM_001252020 NP_001238949 NM_001252024 NP_001238953 NM_001252030 NP_001238959 NM_002420 NP_002411
|
| Function |
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO:0000250, ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:19878917, ECO:0000269|PubMed:19896109}.
|
| Subcellular Location |
Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:11535825}.
|
| Tissue Specificity |
Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. {ECO:0000269|PubMed:11112417, ECO:0000269|PubMed:19896109, ECO:0000269|PubMed:9537257}.
|