| Gene Symbol |
CDK11B
|
| Entrez Gene |
984
|
| Alt Symbol |
CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 11B
|
| Other Description |
CDC-related protein kinase p58|PITSLRE serine/threonine-protein kinase CDC2L1|cell division cycle 2-like 1 (PITSLRE proteins)|cell division protein kinase 11B|galactosyltransferase-associated protein kinase p58/GTA|p58 CLK-1
|
| Swissprots |
Q12817 Q9UP59 Q9UBQ1 Q9UBR0 Q9NZS5 Q9UNY2 Q12819 Q12820 Q8N530 O95265 Q12822 Q9UP57 Q9UBJ0 Q12818 Q9UP58 P21127
|
| Accessions |
AAB59449 AAC83662 AAC83663 AAC83664 AAC83665 AAC83666 EAW56170 EAW56171 EAW56172 EAW56173 P21127 AA778148 AF067512 AAC72077 AF067513 AAC72078 AF067514 AAC72079 AF067515 AAC72080 AF067516 AAC72081 AF067517 AAC72082 AF174497 AAF36538 AK000081 AK295607 BAG58493 AK304679 BAG65451 BC009375 AAH09375 BC054019 BC104661 AAI04662 BC139777 AAI39778 BC140714 AAI40715 BC171773 AAI71773 DB516340 DC295949 DC362247 DC393302 U04816 AAA19582 U04817 AAA19583 U04818 AAA19584 U04824 AAA19586 XM_006711065 XP_006711128 XM_006711071 XP_006711134 XM_011542490 XP_011540792 XM_011542491 XP_011540793 XM_011542492 XP_011540794 XM_011542493 XP_011540795 XM_011542494 XP_011540796 XM_011542495 XP_011540797 XM_011542496 XP_011540798 NM_001291345 NP_001278274 NM_001787 NP_001778 NM_033486 NP_277021 NM_033487 NP_277022 NM_033489 NP_277024 NM_033490 NP_277025 NM_033488 NM_033492 NM_033493
|
| Function |
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:2217177}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. {ECO:0000269|PubMed:8195233, ECO:0000269|PubMed:9750192}.
|