| Gene Symbol |
GPR68
|
| Entrez Gene |
8111
|
| Alt Symbol |
GPR12A, OGR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 68
|
| Other Description |
G-protein coupled receptor 68|ovarian cancer G protein-coupled receptor, 1|ovarian cancer G-protein coupled receptor 1|sphingosylphosphorylcholine receptor
|
| Swissprots |
Q13334 Q6IX34 Q4VBB4 Q15743
|
| Accessions |
AAC50596 EAW81447 EAW81448 Q15743 AY615372 AAT38917 BC067470 AAH67470 BC067471 AAH67471 BC067472 AAH67472 BC069592 AAH69592 BC096071 AAH96071 BC096072 AAH96072 BC096073 AAH96073 BC096074 AAH96074 BC098567 AAH98567 BC128536 AAI28537 BM723705 CN287036 EU883575 ACG60649 HQ447492 ADQ31978 U35398 AAA79060 XM_005268110 XP_005268167 XM_005268111 XP_005268168 XM_005268112 XP_005268169 XM_006720262 XP_006720325 XM_011537196 XP_011535498 XM_011537197 XP_011535499 XM_011537198 XP_011535500 XM_011537199 XP_011535501 XM_011537200 XP_011535502 NM_001177676 NP_001171147 NM_003485 NP_003476
|
| Function |
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. {ECO:0000269|PubMed:12955148}.
|