OPRM1

Gene Symbol OPRM1
Entrez Gene 4988
Alt Symbol LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Species Human
Gene Type protein-coding
Description opioid receptor, mu 1
Other Description mu opiate receptor|mu opioid receptor hMOR-1a|mu-type opioid receptor
Swissprots Q6UPP1 Q12930 E7EWZ3 B2R9S7 Q4VWX6 B8Q1L8 Q7Z2D8 Q6UQ80 Q4VWM6 G8XRH6 P35372 Q9UN57 Q4VWM3 Q5TDA1 Q4VWM1 Q8IWW4 Q4VWM4 Q86V80 Q8IWW3 B8Q1L7 G8XRH8 B0FXJ1 Q9UCZ4 B8Q1L9 Q4VWM2
Accessions AAC51877 AAC51878 AAD44318 AAP44409 AAP44410 AAP58255 AAQ12260 AAS83107 ACJ65060 ACJ65061 ACJ65062 ACJ65063 ACV85685 ACV85686 AIQ84872 AIQ84873 AIQ84874 AIQ84875 AIQ84876 AIQ84877 AKE49348 AKE49349 AKE49350 AKE49351 AKE49352 AKE49353 EAW47704 EAW47705 P35372 AK309655 AK313901 BAG36624 AY036622 AAK74189 AY036623 AAK74190 AY195733 AAO21305 AY225404 AAP44727 AY309001 AAQ77385 AY309005 AAQ77389 AY309006 AAQ77390 AY309007 AAQ77391 AY309008 AAQ77392 AY309009 AAQ77393 AY364230 AAR12887 AY364890 AAR11568 AY521028 AAS00462 BC074927 AAH74927 DQ680044 ABH03503 EF666090 EU340241 ACA49726 EU340242 ACA49727 EU340243 ACA49728 EU360599 ABY61366 EU362990 ABY66530 FJ041290 ACM90348 FJ041291 ACM90349 FJ041292 ACM90350 FJ041293 ACM90351 FJ041294 ACM90352 GQ258059 ACT35692 HQ699462 AET97615 JX914655 AGA35553 L25119 AAA20580 L29301 AAA73958 U12569 AAB60354 XM_006715497 XP_006715560 XM_011535849 XP_011534151 XM_011535850 XP_011534152 XM_011535851 XP_011534153 XM_011535852 XP_011534154 XM_011535853 XP_011534155 XM_011535854 XP_011534156 XM_011535855 XP_011534157 XM_011535856 XP_011534158 XM_011535857 XP_011534159 XM_011535858 XP_011534160 XM_011535859 XP_011534161 XM_011535860 XP_011534162 XM_011535861 XP_011534163 XM_011535862 XP_011534164 NM_000914 NP_000905 NM_001008503 NP_001008503 NM_001008504 NP_001008504 NM_001008505 NP_001008505 NM_001145279 NP_001138751 NM_001145280 NP_001138752 NM_001145281 NP_001138753 NM_001145282 NP_001138754 NM_001145283 NP_001138755 NM_001145284 NP_001138756 NM_001145285 NP_001138757 NM_001145286 NP_001138758 NM_001145287 NP_001138759 NM_001285522 NP_001272451 NM_001285523 NP_001272452 NM_001285524 NP_001272453 NM_001285526 NP_001272455 NM_001285527 NP_001272456 NM_001285528 NP_001272457 NR_104348 NR_104349 NR_104350 NR_104351
Function Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta- gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectif
Subcellular Location Cell membrane {ECO:0000269|PubMed:16580639}; Multi-pass membrane protein {ECO:0000269|PubMed:16580639}.
Tissue Specificity Expressed in brain. Isoform 16 and isoform 17 are detected in brain. {ECO:0000269|PubMed:16580639}.
Top Pathways Morphine addiction, Estrogen signaling pathway, Neuroactive ligand-receptor interaction

Phospho-μ-Opioid Receptor (Ser375) Antibody - 3451 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CHO cells, stably transfected with µ-opioid receptor, untreated or DAMGO-treated (1 mM) for various times, using Phospho-µ-Opioid Receptor (Ser375) Antibody.

MOR-1 (Q-18) - sc-27072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MOR-1 (Q-18): sc-27072. Western blot analysis of MOR-1 expression in EOC 20 (A) and EOC 13.31 (B) whole cell lysates.

MOR-1 (H-80) - sc-15310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MOR-1 (H-80): sc-15310. Western blot analysis of MOR-1 expression in SK-N-MC whole cell lysate (A) and mouse brain extract (B).

MOR-1 (N-20) - sc-7489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MOR-1 (C-20) - sc-7488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MOR-1 (C-20)-R: sc-7488-R. Western blot analysis of MOR-1 expression in mouse brain tissue extract.

Anti-Mu Opioid Receptor (phospho S377) antibody - ab51161 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of human brain tissue (paraffin section) using ab51161 (1/50 dilution); with and without peptide.

Anti-Mu Opioid Receptor antibody - ab17934 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Mu Opioid Receptor antibody - ab64746 from Abcam

Prices $376.00
Sizes 50 µl
Clonality Polyclonal
Ab64746 (1:500) staining of Mu opioid receptor in rat dorsal horn by IHC.

Anti-Mu Opioid Receptor antibody - ab137277 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Mu Opioid Receptor antibody (ab137277) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-Mu Opioid Receptor antibody - ab51155 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
immunohistochemical analysis of Opioid receptor expression in paraffin-embedded human brain tissue using 1/50 ab51155. Left: untreated sample. Right: sample treated with immunizing peptide.

Anti-Mu Opioid Receptor antibody - ab13074 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Mu Opioid Receptor antibody [UMB3] - ab134054 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone UMB3
Overlay histogram showing SH-SY5Y cells stained with ab134054 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab134054, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Mu Opioid Receptor antibody - N-terminal - ab137460 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mu Opioid Receptor antibody - N-terminal (ab137460) at 1/500 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-OPRM1 / Mu Opioid Receptor Antibody (aa384-398) - LS-C17020 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody - LS-C37888 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (phospho-Ser377) - LS-C17026 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (C-Terminus) - LS-C37891 from LifeSpan Bioscience

Prices $435.00
Sizes 5 ml
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (C-Terminus) - LS-C37890 from LifeSpan Bioscience

Prices $635.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (C-Terminus) - LS-C37889 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (C-Terminus) - LS-C131133 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (aa385-398, clone 12K148) - LS-C182922 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K148

Anti-OPRM1 / Mu Opioid Receptor Antibody (phospho-Ser375) - LS-C205422 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (aa161-187, AP) - LS-C265005 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (aa161-187, APC) - LS-C265006 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRM1 / Mu Opioid Receptor Antibody (aa161-187, Biotin) - LS-C265007 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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