SEPT2

Gene Symbol	SEPT2
Entrez Gene	4735
Alt Symbol	DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5
Species	Human
Gene Type	protein-coding
Description	septin 2
Other Description	neural precursor cell expressed developmentally down-regulated protein 5|neural precursor cell expressed, developmentally down-regulated 5|septin-2
Swissprots	Q53QU3 Q14132 B4DGE8 Q96CB0 Q8IUK9 Q15019
Accessions	AAY14718 EAW71258 EAW71259 EAW71260 EAW71261 Q15019 AA482233 AF038404 AAB92377 AK294563 BAG57759 BC014455 AAH14455 BC033559 AAH33559 BC040676 BC043180 BG721140 BI561073 BX648000 D28540 BAA05893 D63878 BAA09928 DB035463 DB091579 DB095611 DQ892247 ABM83173 DQ895447 ABM86373 XM_005247011 XP_005247068 XM_005247012 XP_005247069 XM_005247013 XP_005247070 XM_006712547 XP_006712610 XM_006712548 XP_006712611 XM_006712549 XP_006712612 XM_011511231 XP_011509533 XM_011511232 XP_011509534 XM_011511233 XP_011509535 XM_011511234 XP_011509536 XM_011511235 XP_011509537 XM_011511236 XP_011509538 XM_011511237 XP_011509539 XM_011511238 XP_011509540 XM_011511239 XP_011509541 XM_011511240 XP_011509542 NM_001008491 NP_001008491 NM_001008492 NP_001008492 NM_001282972 NP_001269901 NM_001282973 NP_001269902 NM_004404 NP_004395 NM_006155 NP_006146
Function	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15774761}. Cell projection, cilium membrane {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morp
Tissue Specificity	Widely expressed. Up-regulated in liver cancer. {ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:19165576}.
Top Pathways	Bacterial invasion of epithelial cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Septin 2 full length protein - ab99296 from Abcam Category Protein Source E. coli Species Human

SEPT2 / Septin 2 Antibody Blocking Peptide - LS-E4447 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SEPT2 / Septin 2 Antibody Blocking Peptide - LS-E20603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SEPT2 / Septin 2 Antibody Blocking Peptide - LS-E20604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SEPT2 / Septin 2 Antibody Blocking Peptide - LS-E26877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Septin-2 Recombinant Protein - H00004735-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Septin-2 Recombinant Protein - H00004735-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Septin-2 Protein - NBP1-48589 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E.coli Species Human

SEPT2-Antibody-C-term-Blocking-Peptide - BP16761b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Septin 2 blocking peptide - GTX88523-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

SEPT2 Protein (OPPA02586) - OPPA02586 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human SEPTIN-2 protein - orb169272 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

SEPT2 protein (His tag) - 80R-1479 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

Septin 2 Blocking Peptide - 33R-5309 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Septin 2 Blocking Peptide - 33R-6451 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Septin 2 Peptide - AC21-1712-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Septin-2 (1-361, His-tag) - AR09655PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

Septin-2 (1-361, His-tag) - AR09655PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

Septin-2 - H00004735-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Septin-2 - H00004735-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Septin-2 - H00004735-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Septin-2 - H00004735-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Septin-2 - H00004735-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Septin-2, Human Recombinant - 228-13008-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Septin-2 - 228-13008-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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