SEPT2

Gene Symbol SEPT2
Entrez Gene 4735
Alt Symbol DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5
Species Human
Gene Type protein-coding
Description septin 2
Other Description neural precursor cell expressed developmentally down-regulated protein 5|neural precursor cell expressed, developmentally down-regulated 5|septin-2
Swissprots Q53QU3 Q14132 B4DGE8 Q96CB0 Q8IUK9 Q15019
Accessions AAY14718 EAW71258 EAW71259 EAW71260 EAW71261 Q15019 AA482233 AF038404 AAB92377 AK294563 BAG57759 BC014455 AAH14455 BC033559 AAH33559 BC040676 BC043180 BG721140 BI561073 BX648000 D28540 BAA05893 D63878 BAA09928 DB035463 DB091579 DB095611 DQ892247 ABM83173 DQ895447 ABM86373 XM_005247011 XP_005247068 XM_005247012 XP_005247069 XM_005247013 XP_005247070 XM_006712547 XP_006712610 XM_006712548 XP_006712611 XM_006712549 XP_006712612 XM_011511231 XP_011509533 XM_011511232 XP_011509534 XM_011511233 XP_011509535 XM_011511234 XP_011509536 XM_011511235 XP_011509537 XM_011511236 XP_011509538 XM_011511237 XP_011509539 XM_011511238 XP_011509540 XM_011511239 XP_011509541 XM_011511240 XP_011509542 NM_001008491 NP_001008491 NM_001008492 NP_001008492 NM_001282972 NP_001269901 NM_001282973 NP_001269902 NM_004404 NP_004395 NM_006155 NP_006146
Function Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15774761}. Cell projection, cilium membrane {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morp
Tissue Specificity Widely expressed. Up-regulated in liver cancer. {ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:19165576}.
Top Pathways Bacterial invasion of epithelial cells

Septin 2 (F-1) - sc-514206 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Septin 2 (F-1): sc-514206. Western blot analysis of Septin 2 expression in human brain tissue extract.

Septin 2 (N-12) - sc-20408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Septin 2 (N-12): sc-20408. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lymph node showing cytoplasmic localization.

Anti-Septin 2 antibody - ab186020 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Septin 2 antibody (ab186020) at 0.1 µg/mlLane 1 : HeLa, whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLane 4 : TCMK-1 whole cell lysateLane 5 : NIH3T3 whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-Septin 2 antibody - ab88657 from Abcam

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Septin 2 antibody (ab88657) at 1 µg/ml + human spleen tissue lysate at 50 µg

Anti-Septin 2 antibody - ab115863 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115863 at 2.5ug/ml staining Septin 2 in Formalin-fixed, Paraffin-embedded Human brain (cortex) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Septin 2 antibody - ab79287 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Septin 2 antibody (ab79287) at 0.05 µg/ml + Human Testis lysate (in RIPA buffer) at 35 µg

Anti-Septin 2 antibody - ab125915 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Septin 2 antibody (ab125915) at 1/1000 dilutionLane 1 : U87-MG whole cell lysateLane 2 : SK-N-SH whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Septin 2 antibody [6] - ab178555 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6
Anti-Septin 2 antibody [6] (ab178555) at 1/1000 dilution + HeLa whole cell lysate

Anti-Septin 2 antibody [EPR12122] - ab187654 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12122
Immunofluorescence analysis of MCF7 cells labeling Septin 2 using ab187654 at 1/100 dilution. A Goat anti rabbit IgG (Alexa Fluor488) at 1/200 dilution was used as secondary antibody. Cells were fixed with 4% paraformaldehyde. Counterstain: DAPI.

Anti-Septin 2 antibody [EPR12123] - ab179436 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12123
All lanes : Anti-Septin 2 antibody [EPR12123] (ab179436) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : U87-MG lysateLane 3 : Jurkat lysateLane 4 : MCF-7 lysateLysates/proteins at 10 µg per lane.

Anti-Septin 2 antibody - Aminoterminal end - ab58657 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab58657 staining Septin 2 in murine oocytes by Immunocytochemistry/ Immunofluorescence. The cells were fixed in paraformaldehyde, permeabilised in 0.5% Triton X-100 and then blocked using 1% BSA for 1 hour at 25°C. Samples were then incubated with primary antibody at a 1/25 dilution for 14 hours at 4°C. The secondary antibody used was a goat anti-rabbit IgG conjugated to Cy5®, used undiluted.See Abreview

Anti-Septin 2 antibody - C-terminal - ab185998 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Septin 2 antibody - C-terminal (ab185998) at 0.1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLane 4 : TCMK1 whole cell lysateLane 5 : NIH 3T3 whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-SEPT2 / Septin 2 Antibody (aa37-49) IHC-plus™ - LS-B3607 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SEPT2 / Septin 2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3607 concentration 2.5 ug/ml.

Anti-SEPT2 / Septin 2 Antibody (N-Terminus) - LS-C47110 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (Leu136) - LS-C192137 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa279-309, AP) - LS-C269000 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa279-309, APC) - LS-C269001 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa279-309, Biotin) - LS-C269002 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa279-309, FITC) - LS-C269003 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa279-309, Azide-free, HRP) - LS-C269004 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa87-136) - LS-C200651 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using SEPT2 antibody.

Anti-SEPT2 / Septin 2 Antibody (aa279-309, PE) - LS-C269005 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SEPT2 / Septin 2 Antibody (aa103-152) - LS-C120356 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat/MCF-7 cells, using SEPT2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-SEPT2 / Septin 2 Antibody (aa287-336) - LS-C102711 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SEPT2 / Septin 2 antibody LS-C102711 Western blot of HepG2 cell lysate.

Anti-SEPT2 / Septin 2 Antibody (aa279-309) - LS-C325006 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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