| Gene Symbol | PKP4 |
|---|---|
| Entrez Gene | 8502 |
| Alt Symbol | p0071 |
| Species | Human |
| Gene Type | protein-coding |
| Description | plakophilin 4 |
| Other Description | catenin 4|plakophilin-4 |
| Swissprots | Q99569 Q86W91 |
| Accessions | AAY14929 AAY62612 EAX11425 EAX11426 EAX11427 EAX11428 EAX11429 EAX11430 EAX11431 EAX11432 EAX11433 Q99569 AK054911 AK055015 AK055823 AK124237 AK128720 BC034473 BC041163 BC048013 BC050308 AAH50308 BQ017486 DB473248 U60472 AAQ13346 U81005 AAD00454 X81889 CAA57478 XM_011512016 XP_011510318 XM_011512017 XP_011510319 XM_011512018 XP_011510320 XM_011512019 XP_011510321 XM_011512020 XP_011510322 XM_011512021 XP_011510323 XM_011512022 XP_011510324 XM_011512023 XP_011510325 XM_011512024 XP_011510326 XM_011512025 XP_011510327 XM_011512026 XP_011510328 NM_001005476 NP_001005476 NM_001304969 NP_001291898 NM_001304970 NP_001291899 NM_001304971 NP_001291900 NM_003628 NP_003619 |
| Function | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Subcellular Location | Cell junction, desmosome {ECO:0000269|PubMed:17115030}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17115030}. Midbody {ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:17115030}; Peripheral membrane protein {ECO:0000269|PubMed:17115030}. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells. |
plakophilin 4 CRISPR/Cas9 KO Plasmid (h) - sc-408163 from Santa Cruz Biotechnology
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plakophilin 4 HDR Plasmid (h) - sc-408163-HDR from Santa Cruz Biotechnology
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plakophilin 4 Double Nickase Plasmid (h) - sc-408163-NIC from Santa Cruz Biotechnology
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plakophilin 4 Double Nickase Plasmid (h2) - sc-408163-NIC-2 from Santa Cruz Biotechnology
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plakophilin 4 CRISPR Activation Plasmid (h) - sc-408163-ACT from Santa Cruz Biotechnology
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plakophilin 4 CRISPR Activation Plasmid (h2) - sc-408163-ACT-2 from Santa Cruz Biotechnology
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plakophilin 4 Lentiviral Activation Particles (h) - sc-408163-LAC from Santa Cruz Biotechnology
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plakophilin 4 Lentiviral Activation Particles (h2) - sc-408163-LAC-2 from Santa Cruz Biotechnology
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plakophilin 4 siRNA (h) - sc-43184 from Santa Cruz Biotechnology
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Plakophilin 4 shRNA Plasmid (h) - sc-43184-SH from Santa Cruz Biotechnology
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Plakophilin 4 shRNA (h) Lentiviral Particles - sc-43184-V from Santa Cruz Biotechnology
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Plakophilin 4 RNAi - H00008502-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN16879 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16879 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07039 from Sigma-Aldrich
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PKP4 siRNA (Human) - CRH5576 from Cohesion Biosciences
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Plakophilin 4 RNAi - H00008502-R02 from Novus Biologicals
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shRNA set against Human PKP4 (NM_003628.3) - SHH376632 from Creative biogene
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shRNA set against Human PKP4(NM_001005476.1) - SHR118298 from Creative biogene
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shRNA set against Human PKP4(NM_003628.3) - SHR118316 from Creative biogene
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Human PKP4 siRNA - orb266078 from Biorbyt
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PKP4 shRNA Plasmid (Human) - CHH5576 from Cohesion Biosciences
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PKP4 miRNA 3'UTR clone - MiUTR1H-07951 from Creative biogene
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PKP4 miRNA 3'UTR clone - MiUTR1H-07952 from Creative biogene
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