E2F4

Gene Symbol	E2F4
Entrez Gene	1874
Alt Symbol	E2F-4
Species	Human
Gene Type	protein-coding
Description	E2F transcription factor 4, p107/p130-binding
Other Description	p107/p130-binding protein|transcription factor E2F4
Swissprots	Q15328 Q16254 Q12991 A6NGR8 B5BU56
Accessions	AAF65226 AAM77918 CBX53825 EAW83094 EAW83095 EAW83096 Q16254 AB451292 BAG70106 AB451425 BAG70239 BC021050 BC031071 BC033180 AAH33180 BU857680 DQ892803 ABM83729 S75174 AAB32597 U15641 AAC50119 X86096 CAA60050 NM_001950 NP_001941
Function	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.
Subcellular Location	Nucleus.
Tissue Specificity	Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Cell cycle, TGF-beta signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E2F4 full length protein - ab152352 from Abcam Category Protein Source Wheat germ Species Human

E2F4 Antibody Blocking Peptide - LS-E10862 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human E2F-4 Protein - H00001874-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

E2F4 Blocking Peptide - abx062554 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

E2F4 - H00001874-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

E2F4 - H00001874-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

E2F4 fusion protein - ag1365 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli-derived, PGEX-4T Species Human

Recombinant Human E2F4, GST-tagged - E2F4-12248H from Creative Biomart Category Protein Source E.coli Species Human

E2F4 Blocking Peptide - CBP1360 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

E2F4/E2F5 (L50/83) Peptide - BS1095P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Transcription factor E2F4(E2F4) - CSB-YP621946HU CSB-EP621946HU CSB-BP621946HU CSB-MP621946HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

E2F-4 (108-300) - sc-4098 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

E2F4, Peptide - MBS428160 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Bovine

Transcription factor E2F4, Peptide - MBS428638 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Pig, Bovine

E2F4 Peptide, Human - M34GP04667H from Creative Peptides Category Peptide Source Synthetic. Species Human

E2F-4 Recombinant Protein Antigen - NBP2-58401PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E2F4 peptide - orb72627 from Biorbyt Category Peptide

Recombinant Human E2F4 Protein, GST-tagged - E2F4-3008H from Creative Biomart Category Protein Source Wheat Germ Species Human

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