E2F4

Gene Symbol E2F4
Entrez Gene 1874
Alt Symbol E2F-4
Species Human
Gene Type protein-coding
Description E2F transcription factor 4, p107/p130-binding
Other Description p107/p130-binding protein|transcription factor E2F4
Swissprots Q15328 Q16254 Q12991 A6NGR8 B5BU56
Accessions AAF65226 AAM77918 CBX53825 EAW83094 EAW83095 EAW83096 Q16254 AB451292 BAG70106 AB451425 BAG70239 BC021050 BC031071 BC033180 AAH33180 BU857680 DQ892803 ABM83729 S75174 AAB32597 U15641 AAC50119 X86096 CAA60050 NM_001950 NP_001941
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.
Subcellular Location Nucleus.
Tissue Specificity Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways Cell cycle, TGF-beta signaling pathway

E2F-4 (RK-13) - sc-511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (RK-13): sc-511. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear staining.

E2F-4 (D-7) - sc-398543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (D-7): sc-398543. Western blot analysis of E2F-4 expression in A-673 (A), HeLa (B), A-431 (C) and Y79 (D) nuclear extracts.

E2F-4 (WUF10) - sc-69686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (WUF10): sc-69686. Western blot analysis of E2F-4 expression in HL-60 (A), Raji (B) and Jurkat (C) whole cell lysates.

E2F-4 (WUF11) - sc-56669 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (WUF11): sc-56669. Western blot analysis of E2F-4 expression in HL-60 (A), Raji (B) and Jurkat (C) whole cell lysates.

E2F-4 (A-20) - sc-1082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2F-4 (A-20): sc-1082. Immunofluorescence staining of methanol-fixed Jurkat cells showing nuclear staining.

E2F-4 (C-108) - sc-512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gel supershift analysis of E2F proteins isolated by immunoprecipitation using either p107 (A,B) or Rb p110 (C-E) antibodies. E2F-4 released from p107/E2F complexes and incubated with <sup>32</sup>P-labeled E2F binding sites specific oligonucleotide was supershifted by E2F-4 (C-108) X: sc-512 X antibody (B) as compared to control IgG (A). Similarly, E2F-4 released from Rb p110/E2F complexes was supershifted by E2F-4 (C-108) X: sc-512 X (E), but not by E2F-1 (KH95) X: sc-251 X (D) as compared to control IgG (C). Kindly provided by Masa-aki Ikeda, Ph.D., D.D.S.

E2F-4 (C-20) - sc-866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2F-4 (C-20): sc-866. Western blot analysis of E2F-4 expression in MM-142 (A), 3611-RF (B), HeLa (C), A-431 (D), Y79 (E) and A-673 (F) nuclear extracts.

E2F-4 (WUF2) - sc-69685 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (WUF2): sc-69685. Western blot analysis of E2F-4 expression in HL-60 (A), Raji (B) and Jurkat (C) whole cell lysates.

E2F-4 (D-3) - sc-6851 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (D-3): sc-6851. Western blot analysis of human recombinant E2F-4 fusion protein (A). An unrelated fusion protein with the same tag (B) and the tag alone (C) were included as controls.

E2F-4 (WUF3) - sc-56670 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (WUF3): sc-56670. Western blot analysis of E2F-4 expression in HL-60 (A), Raji (B) and Jurkat (C) whole cell lysates.

E2F-4 (TFE-42) - sc-56668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-4 (TFE-42): sc-56668. Western blot analysis of E2F-4 expression in Y79 (A) and A-431 (B) nuclear extracts and Raji whole cell lysate (C).

Anti-E2F4 (acetyl K96) antibody - ab190767 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-E2F4 (acetyl K96) antibody (ab190767) at 1/500 dilution + L929 cell extract at 30 µg

Anti-E2F4 antibody - ab53060 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F4 antibody (ab53060) at 1/500 dilutionLane 1 : Extracts from COS7 cellsLane 2 : Extracts from COS7 cells treated with peptide

Anti-E2F4 antibody - ab191036 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-E2F4 antibody - ab171815 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-E2F4 antibody (ab171815) at 1/500 dilutionLane 1 : E2F4 transfected 293T cell line lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilutiondeveloped using the ECL technique

Anti-E2F4 antibody [4E2F04] - ab4071 from Abcam

Prices $376.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 4E2F04
ab4071 staining human tonsil by IHC-P.

Anti-E2F4 antibody [4E2F04] (Biotin) - ab79476 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 4E2F04

Anti-E2F4 antibody [EPR8259] - ab150360 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8259
All lanes : Anti-E2F4 antibody [EPR8259] (ab150360) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Raji cell lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-E2F4 antibody [SPM179] - ab17845 from Abcam

Prices $378.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone SPM179
ab17845 staining E2F4 in formalin-fixed, paraffin embedded human tonsil tissue sections.

Anti-E2F4 antibody [SPM179], prediluted - ab54168 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM179
immunohistochemical staining of formalin fixed, paraffin embedded human tonsil tissue section using ab54168.

Anti-E2F4 antibody [WUF11] - ab11951 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone WUF11

Anti-E2F4 antibody [WUF3] - ab11845 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone WUF3

Anti-E2F4 Antibody - LS-C14983 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-E2F4 Antibody (clone 4E2F04, Azide-free) - LS-C87452 from LifeSpan Bioscience

Prices $695.00, $1,085.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone 4E2F04

Anti-E2F4 Antibody (clone 4E2F04, Biotin) - LS-C87451 from LifeSpan Bioscience

Prices $335.00, $775.00, $1,235.00
Sizes 20 µg, 100 µg, 1 ml
Host Mouse
Clonality Monoclonal
Clone 4E2F04
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