Gene Symbol | SLC18A2 |
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Entrez Gene | 6571 |
Alt Symbol | SVAT, SVMT, VAT2, VMAT2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 18 (vesicular monoamine transporter), member 2 |
Other Description | monoamine neurotransmitter transporter|monoamine transporter|solute carrier family 18 (vesicular monoamine), member 2|solute carrier family 18 member 2|synaptic vesicular amine transporter|vesicle monoamine transporter type 2|vesicle monoamine/H+ antiporter|vesicular amine transporter 2 |
Swissprots | Q15876 D3DRC4 Q5VW49 Q4G147 B2RC96 Q9H3P6 Q05940 |
Accessions | BAB19009 CAA63824 EAW49428 EAW49429 EAW49430 Q05940 AK314997 BAG37493 BC030593 AAH30593 BC108927 AAI08928 BC108928 AAI08929 BQ416859 DB458870 L09118 AAA59877 L14269 AAA91853 L23205 AAA61290 X71354 CAA50489 NM_003054 NP_003045 |
Function | Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. |
Subcellular Location | Cytoplasmic vesicle membrane; Multi-pass membrane protein. |
Top Pathways | Synaptic vesicle cycle, Dopaminergic synapse, Amphetamine addiction, Cocaine addiction, Alcoholism |
VMAT 2 CRISPR/Cas9 KO Plasmid (h) - sc-401308 from Santa Cruz Biotechnology
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VMAT 2 HDR Plasmid (h) - sc-401308-HDR from Santa Cruz Biotechnology
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VMAT 2 Double Nickase Plasmid (h) - sc-401308-NIC from Santa Cruz Biotechnology
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VMAT 2 Double Nickase Plasmid (h2) - sc-401308-NIC-2 from Santa Cruz Biotechnology
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VMAT 2 CRISPR Activation Plasmid (h) - sc-401308-ACT from Santa Cruz Biotechnology
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VMAT 2 CRISPR Activation Plasmid (h2) - sc-401308-ACT-2 from Santa Cruz Biotechnology
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VMAT 2 Lentiviral Activation Particles (h) - sc-401308-LAC from Santa Cruz Biotechnology
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VMAT 2 Lentiviral Activation Particles (h2) - sc-401308-LAC-2 from Santa Cruz Biotechnology
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VMAT 2 siRNA (h) - sc-36824 from Santa Cruz Biotechnology
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VMAT 2 shRNA Plasmid (h) - sc-36824-SH from Santa Cruz Biotechnology
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VMAT 2 shRNA (h) Lentiviral Particles - sc-36824-V from Santa Cruz Biotechnology
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VMAT2 RNAi - H00006571-R01 from Novus Biologicals
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MISSION® esiRNA - EHU048841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19442 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19442 from Sigma-Aldrich
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SLC18A2 siRNA (Human) - CRH4460 from Cohesion Biosciences
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SLC18A2 - MBS8238662 from MyBioSource
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shRNA set against Human SLC18A2 (NM_003054.4) - SHH408836 from Creative biogene
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Human SLC18A2 siRNA - orb264962 from Biorbyt
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SLC18A2 shRNA Plasmid (Human) - CHH4460 from Cohesion Biosciences
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SLC18A2 miRNA 3'UTR clone - MiUTR3H-02410 from Creative biogene
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