| Gene Symbol |
PPIA
|
| Entrez Gene |
5478
|
| Alt Symbol |
CYPA, CYPH, HEL-S-69p
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylprolyl isomerase A (cyclophilin A)
|
| Other Description |
PPIase A|T cell cyclophilin|cyclosporin A-binding protein|epididymis secretory sperm binding protein Li 69p|peptidyl-prolyl cis-trans isomerase A|rotamase A
|
| Swissprots |
Q9BRU4 Q3KQW3 Q96IX3 P05092 A8K220 Q9BTY9 Q567Q0 Q6IBU5 Q9UC61 P62937
|
| Accessions |
AAU13906 CAA37039 P62937 AB451307 BAG70121 AB451438 BAG70252 AK026569 AK130101 AK290085 BAF82774 AK290851 BAF83540 AK293003 BAF85692 AK297340 BAG59794 AK316564 BAG38153 AU100120 BC000689 AAH00689 BC003026 AAH03026 BC005320 AAH05320 BC005982 AAH05982 BC007104 AAH07104 BC013915 AAH13915 BC018843 BC037419 BC073992 AAH73992 BC093076 AAH93076 BC106030 AAI06031 BC137057 AAI37058 BC137058 AAI37059 BM806224 BM909285 BU786475 BX347265 BX408703 CD014106 CR456707 CAG32988 D28351 BAA05717 DQ892625 ABM83551 DQ895865 ABM86791 EU794650 ACJ13704 Y00052 CAA68264 NM_001300981 NP_001287910 NM_021130 NP_066953 NM_203430 NM_203431
|
| Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16527992}. Secreted {ECO:0000269|PubMed:16527992}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
|
![Western Blot: Cyclophilin A Overexpression Lysate (Adult Normal) [NBL1-14645] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cyclophilin A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7210_Cyclophilin%2520A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14645-img0002.jpg)