Gene Symbol | AARS |
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Entrez Gene | 16 |
Alt Symbol | CMT2N |
Species | Human |
Gene Type | protein-coding |
Description | alanyl-tRNA synthetase |
Other Description | alaRS|alanine tRNA ligase 1, cytoplasmic|alanine--tRNA ligase, cytoplasmic|alanyl-tRNA synthetase, cytoplasmic|renal carcinoma antigen NY-REN-42 |
Swissprots | Q96FA0 A6NF14 Q53GV7 P49588 B4DR45 |
Accessions | EAW51838 EAW51839 EAW51840 P49588 AK222824 BAD96544 AK225116 AK299098 BAG61157 AK307782 BC011451 AAH11451 BG764123 BU178772 D32050 BAA06808 DQ591736 DQ891634 ABM82560 DQ894824 ABM85750 XR_933220 NM_001605 NP_001596 |
Function | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255|HAMAP-Rule:MF_03133}. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03133}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
AlaRS CRISPR/Cas9 KO Plasmid (h) - sc-404252 from Santa Cruz Biotechnology
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AlaRS HDR Plasmid (h) - sc-404252-HDR from Santa Cruz Biotechnology
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AlaRS Double Nickase Plasmid (h) - sc-404252-NIC from Santa Cruz Biotechnology
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AlaRS Double Nickase Plasmid (h2) - sc-404252-NIC-2 from Santa Cruz Biotechnology
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AlaRS CRISPR Activation Plasmid (h) - sc-404252-ACT from Santa Cruz Biotechnology
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AlaRS CRISPR Activation Plasmid (h2) - sc-404252-ACT-2 from Santa Cruz Biotechnology
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AlaRS Lentiviral Activation Particles (h) - sc-404252-LAC from Santa Cruz Biotechnology
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AlaRS Lentiviral Activation Particles (h2) - sc-404252-LAC-2 from Santa Cruz Biotechnology
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AlaRS siRNA (h) - sc-72474 from Santa Cruz Biotechnology
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AlaRS shRNA Plasmid (h) - sc-72474-SH from Santa Cruz Biotechnology
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AlaRS shRNA (h) Lentiviral Particles - sc-72474-V from Santa Cruz Biotechnology
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Alanyl tRNA synthetase RNAi - H00000016-R01 from Novus Biologicals
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MISSION® esiRNA - EHU048881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2611 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02141 from Sigma-Aldrich
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AARS siRNA (Human) - CRH0009 from Cohesion Biosciences
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AARS - MBS8216528 from MyBioSource
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AARS shRNA Plasmid (Human) - CHH0009 from Cohesion Biosciences
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