Gene Symbol | DNAJC15 |
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Entrez Gene | 29103 |
Alt Symbol | DNAJD1, HSD18, MCJ |
Species | Human |
Gene Type | protein-coding |
Description | DnaJ (Hsp40) homolog, subfamily C, member 15 |
Other Description | DNAJ domain-containing|DnaJ (Hsp40) homolog, subfamily D, member 1|cell growth-inhibiting gene 22 protein|dnaJ homolog subfamily C member 15|methylation-controlled J protein |
Swissprots | B2R4L0 Q6X963 Q5T219 Q9Y5T4 |
Accessions | EAX08688 Q9Y5T4 AF126743 AAD38506 AJ270691 AK311866 BAG34807 AY248898 AAP20049 AY512565 AAS80157 BC010910 AAH10910 BC095400 AAH95400 CA444534 JF432554 ADZ15771 NM_013238 NP_037370 |
Function | Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:23263864, ECO:0000269|PubMed:23530063}; Single-pass membrane protein {ECO:0000269|PubMed:23263864, ECO:0000269|PubMed:23530063}. |
Tissue Specificity | Expressed at highest levels in heart, followed by liver and kidney. {ECO:0000269|PubMed:11358853, ECO:0000269|PubMed:23530063}. |
MCJ CRISPR/Cas9 KO Plasmid (h) - sc-412031 from Santa Cruz Biotechnology
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MCJ HDR Plasmid (h) - sc-412031-HDR from Santa Cruz Biotechnology
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MCJ Double Nickase Plasmid (h) - sc-412031-NIC from Santa Cruz Biotechnology
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MCJ Double Nickase Plasmid (h2) - sc-412031-NIC-2 from Santa Cruz Biotechnology
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MCJ CRISPR Activation Plasmid (h) - sc-412031-ACT from Santa Cruz Biotechnology
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MCJ CRISPR Activation Plasmid (h2) - sc-412031-ACT-2 from Santa Cruz Biotechnology
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MCJ Lentiviral Activation Particles (h) - sc-412031-LAC from Santa Cruz Biotechnology
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MCJ Lentiviral Activation Particles (h2) - sc-412031-LAC-2 from Santa Cruz Biotechnology
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MCJ siRNA (h) - sc-75761 from Santa Cruz Biotechnology
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MCJ shRNA Plasmid (h) - sc-75761-SH from Santa Cruz Biotechnology
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MCJ shRNA (h) Lentiviral Particles - sc-75761-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU013601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7363 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7363 from Sigma-Aldrich
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DNAJC15 siRNA (Human) - CRH9194 from Cohesion Biosciences
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DNAJC15 - MBS8214857 from MyBioSource
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shRNA set against Human DNAJC15 (NM_013238.2) - SHH279489 from Creative biogene
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shRNA set against Human DNAJC15(NM_013238.2) - SHH010541 from Creative biogene
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Human DNAJC15 siRNA - orb269696 from Biorbyt
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DNAJC15 shRNA Plasmid (Human) - CHH9194 from Cohesion Biosciences
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DNAJC15 miRNA 3'UTR clone - MiUTR1H-02921 from Creative biogene
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