| Gene Symbol |
OXCT1
|
| Entrez Gene |
5019
|
| Alt Symbol |
OXCT, SCOT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-oxoacid CoA transferase 1
|
| Other Description |
3-oxoacid CoA-transferase 1|3-oxoacid-CoA transferase 1|SCOT-s|somatic-type succinyl CoA:3-oxoacid CoA-transferase|somatic-type succinyl-CoA:3-oxoacid CoA-transferase|somatic-type succinyl-CoA:3-oxoacid-CoA-transferase|succinyl CoA:3-oxoacid CoA transferase|succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial|succinyl-CoA:3-ketoacid-CoA transferase|succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
|
| Swissprots |
P55809 B7Z528 B2R5V2
|
| Accessions |
BAB13733 BAC19838 CBX51364 EAW56014 EAW56015 P55809 AK125115 AK298352 BAH12764 AK299668 BAH13095 AK312327 BAG35249 AK315902 BAH14273 BC009001 AAH09001 BE244429 CR457049 CAG33330 DQ891805 ABM82731 DQ894989 ABM85915 EF095213 ABL01517 U62961 AAB07366 XR_427658 NM_000436 NP_000427
|
| Function |
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
|
| Subcellular Location |
Mitochondrion matrix.
|
| Tissue Specificity |
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
|
| Top Pathways |
Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism
|
![Western Blot: OXCT1 Overexpression Lysate (Adult Normal) [NBL1-14018] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OXCT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9367_OXCT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14018-img0002.jpg)