| Gene Symbol |
SLC4A11
|
| Entrez Gene |
83959
|
| Alt Symbol |
BTR1, CDPD1, CHED2, NABC1, dJ794I6.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 4, sodium borate transporter, member 11
|
| Other Description |
bicarbonate transporter related protein 1|sodium bicarbonate transporter-like protein 11|sodium-coupled borate cotransporter 1|solute carrier family 4, sodium bicarbonate transporter-like, member 11
|
| Swissprots |
B4DKX9 Q9NTW9 Q2TB63 G3V1M3 Q9BXF4 Q8NBS3 Q2TB62 B4DKC8
|
| Accessions |
AGN70982 AGN70983 AGN70984 AGN70985 AGN70986 AGN70987 AGN70988 AGN70989 AGN70990 AGN70991 AGN70992 AGN70993 AGN70994 AGN70995 AGN70996 AGN70997 AGN70998 AGN70999 AGN71000 AGN71001 AGN71002 AGN71003 EAX10535 EAX10536 EAX10537 EAX10538 EAX10539 Q8NBS3 AF336127 AAK16734 AK075303 BAC11536 AK091157 AK296508 BAG59140 AK296760 BAG59341 BC110540 AAI10541 BC110541 AAI10542 BM666654 CA312226 DC341640 XM_005260856 XP_005260913 XM_005260857 XP_005260914 XM_011529383 XP_011527685 XM_011529384 XP_011527686 XM_011529385 XP_011527687 XM_011529386 XP_011527688 XR_937167 NM_001174089 NP_001167560 NM_001174090 NP_001167561 NM_032034 NP_114423
|
| Function |
Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. {ECO:0000250, ECO:0000269|PubMed:15525507}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18024964}. Membrane {ECO:0000269|PubMed:18024964}; Multi-pass membrane protein {ECO:0000269|PubMed:18024964}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes. {ECO:0000269|PubMed:11302728, ECO:0000269|PubMed:16767101}.
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