POFUT2

Gene Symbol POFUT2
Entrez Gene 23275
Alt Symbol C21orf80, FUT13
Species Human
Gene Type protein-coding
Description protein O-fucosyltransferase 2
Other Description GDP-fucose protein O-fucosyltransferase 2|O-FucT-2|peptide-O-fucosyltransferase 2
Swissprots Q9BQS4 Q8WWU6 Q6PJV1 Q9BQS5 Q9Y2G5 Q9UFY3 Q7Z4N0
Accessions CAB90496 EAX09350 EAX09351 EAX09352 EAX09353 EAX09354 Q9Y2G5 AB023175 BAA76802 AJ302079 CAC24556 AJ302080 CAC24557 AJ575591 CAE01472 AK290732 BAF83421 AK294966 BAG58039 AK298080 BAG60368 AL110285 CAB53715 AY066015 AAL47681 BC000626 BC011044 AAH11044 BC064623 AAH64623 BI560842 BI669244 CA425603 CN429387 HG380510 CDG37810 HG380511 CDG37811 XM_006723981 XP_006724044 XM_011529504 XP_011527806 XM_011529505 XP_011527807 XM_011529506 XP_011527808 XM_011529507 XP_011527809 XM_011529508 XP_011527810 XM_011529509 XP_011527811 XM_011529510 XP_011527812 XM_011529511 XP_011527813 XM_011529512 XP_011527814 XM_011529513 XP_011527815 XR_937452 XR_937454 XR_937455 XR_937456 NM_133634 NM_015227 NP_056042 NM_133635 NP_598368 NR_004858
Function Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. {ECO:0000250, ECO:0000269|PubMed:11067851, ECO:0000269|PubMed:16464858, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082}.
Subcellular Location Endoplasmic reticulum {ECO:0000269|PubMed:15233996}. Golgi apparatus {ECO:0000269|PubMed:15233996}. Note=Mainly located in the endoplasmic reticulum.
Tissue Specificity Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart. {ECO:0000269|PubMed:15233996}.
Top Pathways Other types of O-glycan biosynthesis

POFUT2-Over-expression-Lysate - LY15918a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag POFUT2 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the POFUT2 gene‘

POFUT2 overexpression lysate - LY408775 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

POFUT2 overexpression lysate - LY414699 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

POFUT2 293 Cell Lysate - 404766 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

POFUT2 Overexpression Lysate (Native) - NBL1-14565 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

POFUT2 (h): 293T Lysate - sc-116920 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

POFUT2 Over-expression Lysate Product - GWB-5B23D1 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human POFUT2 Knockdown Stable Cell Line - CSC-DC012058 from Creative biogene

Category Cell Line
Species Human
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