POFUT2

Gene Symbol	POFUT2
Entrez Gene	23275
Alt Symbol	C21orf80, FUT13
Species	Human
Gene Type	protein-coding
Description	protein O-fucosyltransferase 2
Other Description	GDP-fucose protein O-fucosyltransferase 2|O-FucT-2|peptide-O-fucosyltransferase 2
Swissprots	Q9BQS4 Q8WWU6 Q6PJV1 Q9BQS5 Q9Y2G5 Q9UFY3 Q7Z4N0
Accessions	CAB90496 EAX09350 EAX09351 EAX09352 EAX09353 EAX09354 Q9Y2G5 AB023175 BAA76802 AJ302079 CAC24556 AJ302080 CAC24557 AJ575591 CAE01472 AK290732 BAF83421 AK294966 BAG58039 AK298080 BAG60368 AL110285 CAB53715 AY066015 AAL47681 BC000626 BC011044 AAH11044 BC064623 AAH64623 BI560842 BI669244 CA425603 CN429387 HG380510 CDG37810 HG380511 CDG37811 XM_006723981 XP_006724044 XM_011529504 XP_011527806 XM_011529505 XP_011527807 XM_011529506 XP_011527808 XM_011529507 XP_011527809 XM_011529508 XP_011527810 XM_011529509 XP_011527811 XM_011529510 XP_011527812 XM_011529511 XP_011527813 XM_011529512 XP_011527814 XM_011529513 XP_011527815 XR_937452 XR_937454 XR_937455 XR_937456 NM_133634 NM_015227 NP_056042 NM_133635 NP_598368 NR_004858
Function	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. {ECO:0000250, ECO:0000269|PubMed:11067851, ECO:0000269|PubMed:16464858, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082}.
Subcellular Location	Endoplasmic reticulum {ECO:0000269|PubMed:15233996}. Golgi apparatus {ECO:0000269|PubMed:15233996}. Note=Mainly located in the endoplasmic reticulum.
Tissue Specificity	Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart. {ECO:0000269|PubMed:15233996}.
Top Pathways	Other types of O-glycan biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POFUT2 (H-5) - sc-373804 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

POFUT2 (G-1) - sc-271239 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

POFUT2 (W-19) - sc-74993 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

POFUT2 (S-20) - sc-74992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-POFUT2 antibody - ab171152 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 antibody - ab65738 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 antibody - ab110922 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa361-410) - LS-C120003 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa228-257, APC) - LS-C239263 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa228-257, AP) - LS-C239264 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa228-257, Biotin) - LS-C239265 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa228-257, FITC) - LS-C239266 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa38-87) - LS-C80780 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa228-257, Azide-free, HRP) - LS-C248516 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa228-257, PE) - LS-C239267 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (clone 3C12) - LS-C174079 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3C12

Anti-POFUT2 Antibody (aa351-400) - LS-C80779 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (aa235-265) - LS-C324153 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (clone 1A6) - LS-C174078 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1A6

Anti-POFUT2 Antibody (clone 3A12) - LS-C174073 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3A12

Anti-POFUT2 Antibody (aa228-257) - LS-C163835 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 Antibody (clone 5H1) - LS-C174087 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5H1

POFUT2 Antibody - NBP1-58054 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

POFUT2 Antibody - NBP1-58053 from Novus Biologicals Prices $139.00, $299.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

Anti-POFUT2 (AB1) antibody produced in rabbit - AV45855 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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