| Gene Symbol | CHST4 |
|---|---|
| Entrez Gene | 10164 |
| Alt Symbol | GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 |
| Other Description | GST-3|HEC-GlcNAc6ST|L-selectin ligand sulfotransferase|N-acetylglucosamine 6-O-sulfotransferase 2|carbohydrate sulfotransferase 4|galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3|glcNAc6ST-2|gn6st-2|high endothelial cells N-acetylglucosamine 6-O-sulfotransferase |
| Swissprots | Q9Y5R3 Q8NCG5 Q8IV46 |
| Accessions | EAW59235 Q8NCG5 AF131235 AAD33015 AF149783 AAK48417 AF280088 AAG48246 AK026635 AK074746 BAC11177 AL709927 BC035282 AAH35282 DA045171 DA496702 DQ892110 ABM83036 DQ895304 ABM86230 NM_001166395 NP_001159867 NM_005769 NP_005760 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678}. |
| Tissue Specificity | Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues. Expressed in colonic mucinous adenocarcinoma. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:12107080}. |
| Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |