CHST4

Gene Symbol CHST4
Entrez Gene 10164
Alt Symbol GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST
Species Human
Gene Type protein-coding
Description carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Other Description GST-3|HEC-GlcNAc6ST|L-selectin ligand sulfotransferase|N-acetylglucosamine 6-O-sulfotransferase 2|carbohydrate sulfotransferase 4|galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3|glcNAc6ST-2|gn6st-2|high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
Swissprots Q9Y5R3 Q8NCG5 Q8IV46
Accessions EAW59235 Q8NCG5 AF131235 AAD33015 AF149783 AAK48417 AF280088 AAG48246 AK026635 AK074746 BAC11177 AL709927 BC035282 AAH35282 DA045171 DA496702 DQ892110 ABM83036 DQ895304 ABM86230 NM_001166395 NP_001159867 NM_005769 NP_005760
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678}.
Tissue Specificity Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues. Expressed in colonic mucinous adenocarcinoma. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:12107080}.
Top Pathways Glycosaminoglycan biosynthesis - keratan sulfate

HEC-GlcNAc6ST CRISPR/Cas9 KO Plasmid (h) - sc-411422 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST HDR Plasmid (h) - sc-411422-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST Double Nickase Plasmid (h) - sc-411422-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST Double Nickase Plasmid (h2) - sc-411422-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST CRISPR Activation Plasmid (h) - sc-411422-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST CRISPR Activation Plasmid (h2) - sc-411422-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST Lentiviral Activation Particles (h) - sc-411422-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST Lentiviral Activation Particles (h2) - sc-411422-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HEC-GlcNAc6ST siRNA (h) - sc-60776 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HEC-GlcNAc6ST shRNA Plasmid (h) - sc-60776-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HEC-GlcNAc6ST shRNA (h) Lentiviral Particles - sc-60776-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Carbohydrate Sulfotransferase 4/CHST4 RNAi - H00010164-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU013131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6112 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6112 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHST4 siRNA (Human) - CRH6863 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHST4 - MBS8228991 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CHST4 (NM_005769.2) - SHH263813 from Creative biogene

Category siRNA
Species Reactivities Human

CHST4 shRNA Plasmid (Human) - CHH6863 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CHST4 miRNA 3'UTR clone - MiUTR4H-TG02100 from Creative biogene

Species Reactivities Human
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