CHST4

Gene Symbol	CHST4
Entrez Gene	10164
Alt Symbol	GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST
Species	Human
Gene Type	protein-coding
Description	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Other Description	GST-3|HEC-GlcNAc6ST|L-selectin ligand sulfotransferase|N-acetylglucosamine 6-O-sulfotransferase 2|carbohydrate sulfotransferase 4|galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3|glcNAc6ST-2|gn6st-2|high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
Swissprots	Q9Y5R3 Q8NCG5 Q8IV46
Accessions	EAW59235 Q8NCG5 AF131235 AAD33015 AF149783 AAK48417 AF280088 AAG48246 AK026635 AK074746 BAC11177 AL709927 BC035282 AAH35282 DA045171 DA496702 DQ892110 ABM83036 DQ895304 ABM86230 NM_001166395 NP_001159867 NM_005769 NP_005760
Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678}.
Tissue Specificity	Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues. Expressed in colonic mucinous adenocarcinoma. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:12107080}.
Top Pathways	Glycosaminoglycan biosynthesis - keratan sulfate

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Carbohydrate sulfotransferase 4 full length protein - ab160853 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Carbohydrate sulfotransferase 4 protein fragment - ab160854 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CHST4 / GlcNAc6ST2 Antibody Blocking Peptide - LS-E12722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHST4 / GlcNAc6ST2 Antibody Blocking Peptide - LS-E12721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Carbohydrate Sulfotransferase 4/CHST4 Partial Recombinant Protein - H00010164-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Carbohydrate Sulfotransferase 4/CHST4 Protein - H00010164-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human CHST4, CF - 5357-ST-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, His29-His386, with an N-terminal 6-His tag

CHST4 - H00010164-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

CHST4 - H00010164-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CHST4 - H00010164-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHST4 fusion protein - Ag3987 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human CHST4, His-tagged - CHST4-11230H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CHST4, His-tagged - CHST4-561H from Creative Biomart Category Protein Source CHO Cells Species Human

Recombinant Human Carbohydrate sulfotransferase 4(CHST4) - CSB-YP836716HU CSB-EP836716HU CSB-BP836716HU CSB-MP836716HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CHST4 Protein, CF - 5357-ST from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source Chinese Hamster Ovary cell line, CHO-derived His29-His386, with an N-terminal 6-His tag Species Human

Carbohydrate Sulfotransferase 4, Recombinant Protein - MBS636454 from MyBioSource Category Protein Prices $710.00 Sizes 20 µg Species Mouse

Carbohydrate Sulfotransferase 4, Recombinant Protein - MBS636879 from MyBioSource Category Protein Prices $730.00 Sizes 20 µg Species Mouse

Carbohydrate sulfotransferase 4 (CHST4), Recombinant Protein - MBS1467403 from MyBioSource Category Protein Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Carbohydrate Sulfotransferase 4/CHST4 Recombinant Protein Antigen - NBP1-91748PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

CHST4-Blocking-Peptide-C-term - BP21310b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHST4 Peptide, Human - M34GP03153H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human CHST4 Protein, CF - 5357-ST from Novus Biologicals Category Protein Prices $329.00 Sizes 20 µg Species Human

Recombinant Mouse CHST4 Protein, CF - 5547-ST from Novus Biologicals Category Protein Prices $329.00 Sizes 20 µg

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