Gene Symbol | DUSP7 |
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Entrez Gene | 1849 |
Alt Symbol | MKPX, PYST2 |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 7 |
Other Description | dual specificity protein phosphatase 7|dual specificity protein phosphatase PYST2|dual-specificity phosphatase-7 |
Swissprots | Q16829 Q8NFJ0 Q2M3J7 |
Accessions | EAW65184 Q16829 AF508727 AAM77606 AF508728 AL110157 BC019107 AAH19107 BC104880 AAI04881 BC104882 AAI04883 BC128064 CN429806 DN999200 X93921 CAA63814 NM_001947 NP_001938 |
Function | Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors. {ECO:0000269|PubMed:14603440}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells. {ECO:0000269|PubMed:14576828}. |
Top Pathways | MAPK signaling pathway |
PYST2 CRISPR/Cas9 KO Plasmid (h) - sc-404642 from Santa Cruz Biotechnology
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PYST2 HDR Plasmid (h) - sc-404642-HDR from Santa Cruz Biotechnology
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PYST2 Double Nickase Plasmid (h) - sc-404642-NIC from Santa Cruz Biotechnology
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PYST2 Double Nickase Plasmid (h2) - sc-404642-NIC-2 from Santa Cruz Biotechnology
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PYST2 CRISPR Activation Plasmid (h) - sc-404642-ACT from Santa Cruz Biotechnology
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PYST2 CRISPR Activation Plasmid (h2) - sc-404642-ACT-2 from Santa Cruz Biotechnology
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PYST2 Lentiviral Activation Particles (h) - sc-404642-LAC from Santa Cruz Biotechnology
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PYST2 Lentiviral Activation Particles (h2) - sc-404642-LAC-2 from Santa Cruz Biotechnology
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PYST2 siRNA (h) - sc-61427 from Santa Cruz Biotechnology
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PYST2 shRNA Plasmid (h) - sc-61427-SH from Santa Cruz Biotechnology
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PYST2 shRNA (h) Lentiviral Particles - sc-61427-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014341 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0145 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0146 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0147 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7560 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7560 from Sigma-Aldrich
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DUSP7 siRNA (Human) - CRH1297 from Cohesion Biosciences
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DUSP7 RNAi - H00001849-R01 from Novus Biologicals
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DUSP7 - MBS8209196 from MyBioSource
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shRNA set against Human DUSP7 (NM_001947.3) - SHH281913 from Creative biogene
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Human DUSP7 siRNA - orb261799 from Biorbyt
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DUSP7 shRNA Plasmid (Human) - CHH1297 from Cohesion Biosciences
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DUSP7 miRNA 3'UTR clone - MiUTR3H-05291 from Creative biogene
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