| Gene Symbol |
FEZF1
|
| Entrez Gene |
389549
|
| Alt Symbol |
FEZ, HH22, ZNF312B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FEZ family zinc finger 1
|
| Other Description |
fez family zinc finger protein 1|zinc finger protein 312B
|
| Swissprots |
B7ZM98 A0PJY2 A0PJY3 A4D0W3 B4DUP9
|
| Accessions |
A0PJY2 EAL24342 EAW83568 AK300742 BAG62411 AY726588 BC127714 AAI27715 BC127715 AAI27716 BC136684 AAI36685 BC144367 AAI44368 CB104829 DC386457 HY206093 XM_005250337 XP_005250394 XM_011516200 XP_011514502 XM_011516201 XP_011514503 XM_011516202 XP_011514504 NM_001024613 NP_001019784 NM_001160264 NP_001153736
|
| Function |
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19318583}.
|
| Tissue Specificity |
Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues. {ECO:0000269|PubMed:19318583}.
|