Gene Symbol | GALE |
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Entrez Gene | 2582 |
Alt Symbol | SDR1E1 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-galactose-4-epimerase |
Other Description | UDP galactose-4'-epimerase|UDP-GalNAc 4-epimerase|UDP-GlcNAc 4-epimerase|UDP-N-acetylgalactosamine 4-epimerase|UDP-N-acetylglucosamine 4-epimerase|UDP-galactose 4-epimerase|UDP-glucose 4-epimerase|galactose-4-epimerase, UDP-|galactowaldenase|short chain dehydrogenase/reductase family 1E, member 1 |
Swissprots | Q86W41 Q14376 Q9UJB4 A0A024RAH5 Q9BVE3 Q38G75 B3KQ39 |
Accessions | AAC39645 ABB04109 CBX87741 EAW95083 EAW95084 EAW95085 EAW95086 EAW95087 EAW95088 EAW95089 EAW95090 EAW95091 EAW95092 EAW95093 Q14376 AK057302 BAG51901 AK096127 AK307354 AK314397 BAG37021 AL530475 BC001273 AAH01273 BC050685 AAH50685 BC056880 BI835132 BQ437612 DA043957 DQ233668 ABB04110 DQ891753 ABM82679 DQ894934 ABM85860 L41668 AAB86498 NM_000403 NP_000394 NM_001008216 NP_001008217 NM_001127621 NP_001121093 |
Function | Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. {ECO:0000269|PubMed:22654673, ECO:0000303|PubMed:23732289}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism, Galactose metabolism |
GALE 293T Cell Transient Overexpression Lysate(Denatured) - H00002582-T01 from Acris Antibodies
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GALE overexpression lysate - LY423394 from Acris Antibodies
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GALE overexpression lysate - LY424739 from Acris Antibodies
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GALE overexpression lysate - LY426826 from Acris Antibodies
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GALE 293 Cell Lysate - 409928 from ABBIOTEC
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GALE 293 Cell Lysate - 410236 from ABBIOTEC
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GALE Overexpression Lysate (Denatured) - H00002582-T01 from Novus Biologicals
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GALE Overexpression Lysate (Native) - NBL1-10946 from Novus Biologicals
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GALE Overexpression Lysate (Native) - NBL1-10947 from Novus Biologicals
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GALE (h): 293T Lysate - sc-110864 from Santa Cruz Biotechnology
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GALE (h2): 293T Lysate - sc-116373 from Santa Cruz Biotechnology
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GALE (h4): 293T Lysate - sc-170673 from Santa Cruz Biotechnology
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GALE Over-expression Lysate Product - GWB-A7238E from Genway Biotech
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GALE Over-expression Lysate Product - GWB-67B175 from Genway Biotech
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GALE Overexpression Lysate (Native) - NBP2-09454 from Novus Biologicals
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Panoply™ Human GALE Knockdown Stable Cell Line - CSC-DC006069 from Creative biogene
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