Rock2

Gene Symbol	Rock2
Entrez Gene	25537
Alt Symbol	ROCK-II, ROK
Species	Rat
Gene Type	protein-coding
Description	Rho-associated coiled-coil containing protein kinase 2
Other Description	ROKalpha|Rho-associated coiled-coil forming kinase 2|RhoA - binding serine/threosine kinase alpha (ROK - alpha)|p150 ROK-alpha|p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase 2|rho-associated, coiled-coil-containing protein kinase II|rhoA-binding kinase 2
Swissprots	Q62868
Accessions	EDM03141 Q62868 BF398321 CB691694 CK475383 FQ224296 U38481 AAB37540 XM_006239909 XP_006239971 XM_008764574 XP_008762796 XM_008764575 XP_008762797 NM_013022 NP_037154
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important r
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
Tissue Specificity	Highly expressed in brain, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:8816443}.
Top Pathways	cAMP signaling pathway, Sphingolipid signaling pathway, Proteoglycans in cancer, Chemokine signaling pathway, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2), Rat, ELISA Kit - SEB852Ra from ARP American Research Products Category ELISA Kit Prices $667.80 Sizes 96 t Sensitivity 0.108ng/mL Range 0.312-20ng/mL

Rho-associated protein kinase 2 (ROCK2), Rat, ELISA Kit - CSB-EL020059RA from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

Rho-associated protein kinase 2, Rock2, Rat, ELISA Kit - E1852r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Rho-associated, coiled-coil containing protein kinase 2, ELISA Kit - MBS942800 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of rat ROCK2 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 62.5 pg/ml -4000 pg/ml.

Rat Rho-associated protein kinase 2(ROCK2) ELISA kit - CSB-EL020059RA from Cusabio Category ELISA Kit Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

Rat Rock2 ELISA Kit - abx156051 from Abbexa Category ELISA Kit Sensitivity 0.108 ng/ml Range 0.313 ng/ml - 20 ng/ml

Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2), Rat, ELISA Kit - DL-Rock2-Ra from ARP American Research Products Category ELISA Kit Prices $715.00 Sizes 96 t Range 0.312-20 ng/mL

Rat Rock2 ELISA Kit - abx573065 from Abbexa Category ELISA Kit Sensitivity 0.108 ng/ml Range 0.313 ng/ml - 20 ng/ml

Rat Rock2 ELISA Kit - E096291 from Biobool Category ELISA Kit

ROCK2 ELISA Kit (Rat) (OKEH06433) - OKEH06433 from Aviva Systems Biology Category ELISA Kit Prices $440.00 Sizes 96 wells Sensitivity 1.56 ng/mL Range 1.56-100 ng/mL

Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2), ELISA Kit - MBS455571 from MyBioSource Category ELISA Kit Prices $425.00, $565.00, $2,485.00, $4,830.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.108ng/mL Range 0.312-20ng/mL

Rho-associated protein kinase 2, ELISA Kit - MBS2882746 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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