| Gene Symbol |
Rock2
|
| Entrez Gene |
25537
|
| Alt Symbol |
ROCK-II, ROK
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
Rho-associated coiled-coil containing protein kinase 2
|
| Other Description |
ROKalpha|Rho-associated coiled-coil forming kinase 2|RhoA - binding serine/threosine kinase alpha (ROK - alpha)|p150 ROK-alpha|p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase 2|rho-associated, coiled-coil-containing protein kinase II|rhoA-binding kinase 2
|
| Swissprots |
Q62868
|
| Accessions |
EDM03141 Q62868 BF398321 CB691694 CK475383 FQ224296 U38481 AAB37540 XM_006239909 XP_006239971 XM_008764574 XP_008762796 XM_008764575 XP_008762797 NM_013022 NP_037154
|
| Function |
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important r
|
| Subcellular Location |
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
|
| Tissue Specificity |
Highly expressed in brain, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:8816443}.
|
| Top Pathways |
cAMP signaling pathway, Sphingolipid signaling pathway, Proteoglycans in cancer, Chemokine signaling pathway, cGMP-PKG signaling pathway
|