NFE2

Gene Symbol	NFE2
Entrez Gene	4778
Alt Symbol	NF-E2, p45
Species	Human
Gene Type	protein-coding
Description	nuclear factor, erythroid 2
Other Description	leucine zipper protein NF-E2|nuclear factor (erythroid-derived 2), 45kD|nuclear factor (erythroid-derived 2), 45kDa|nuclear factor, erythroid-derived 2 45 kDa subunit|p45 NF-E2|transcription factor NF-E2 45 kDa subunit
Swissprots	Q6ICV9 Q16621 Q07720
Accessions	ABC79302 CCQ43105 CCQ77681 EAW96771 EAW96772 EAW96773 Q16621 AK290555 BAF83244 AK290564 BAF83253 AK313207 BAG36023 BC005044 AAH05044 BE243330 BT007288 AAP35952 BX406317 CR450284 CAG29280 DQ893437 ABM84363 DQ896796 ABM87795 EU176417 ABW03868 GD141614 GU068583 ACY92458 L13974 AAA35612 L24122 AAA16118 S77763 AAB34115 XM_005268906 XP_005268963 XM_011538397 XP_011536699 NM_001136023 NP_001129495 NM_001261461 NP_001248390 NM_006163 NP_006154
Function	Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}.
Subcellular Location	Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Tissue Specificity	Expressed in hematopoietic cells and also in colon and testis.

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• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NFE2-Over-expression-Lysate - LY12979a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

NFE2 293 Cell Lysate - 401653 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Nuclear Factor Erythroid Derived 2 Overexpression Lysate (Native) - NBL1-13612 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NFE2 Over-expression Lysate Product - GWB-24BE30 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Nuclear Factor Erythroid Derived 2 Overexpression Lysate (Native) - NBP2-11086 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human NFE2 Knockdown Stable Cell Line - CSC-DC010332 from Creative biogene Category Cell Line Species Human

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