SCN1B

Gene Symbol	SCN1B
Entrez Gene	6324
Alt Symbol	ATFB13, BRGDA5, GEFSP1
Species	Human
Gene Type	protein-coding
Description	sodium channel, voltage gated, type I beta subunit
Other Description	sodium channel beta-1 subunit|sodium channel subunit beta-1|sodium channel, voltage-gated, type I, beta subunit
Swissprots	Q5TZZ4 Q6TN97 Q07699
Accessions	AAB97608 AAC41946 ABQ01236 Q07699 AK295477 BAG58404 AK313279 BAG36087 AY391842 AAR25552 BC021266 AAH21266 BC030193 BC067122 AAH67122 BC112922 AAI12923 BF194996 BM805468 BT019923 AAV38726 L10338 AAA60391 L16242 AAA61277 XM_005259144 XP_005259201 NM_001037 NP_001028 NM_199037 NP_950238
Function	Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. {ECO:0000269|PubMed:14622265}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level). {ECO:0000269|PubMed:14622265}.
Top Pathways	Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SCN1B full length protein - ab159480 from Abcam Category Protein Source Wheat germ Species Human

SCN1B Antibody Blocking Peptide - LS-E369 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SCN1B Antibody Blocking Peptide - LS-E12476 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SCN1B Antibody Blocking Peptide - LS-E12650 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SCN1B Protein - H00006324-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

SCN1B-Antibody-N-Term-Blocking-Peptide - BP10645a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SCN1B Blocking Peptide - 33R-6928 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SCN1B - H00006324-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SCN1B - H00006324-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SCN1B fusion protein - Ag2017 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SCN1B, GST-tagged - SCN1B-2535H from Creative Biomart Category Protein Source E.coli Species Human

SCN1B Peptide, Human - M34GP13865H from Creative Peptides Category Peptide Source Synthetic. Species Human

Sodium channel subunit beta-1, Recombinant Protein - MBS7043268 from MyBioSource Category Protein Prices $1,015.00, $2,005.00, $3,215.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Chimpanzee

Sodium channel subunit beta-1 (SCN1B), Recombinant Protein - MBS7056969 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Chimpanzee

Sodium channel subunit beta-1 (SCN1B), Recombinant Protein - MBS1152715 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Chimpanzee

Recombinant Human SCN1B Protein, GST-tagged - SCN1B-48H from Creative Biomart Category Protein Source Wheat Germ Species Human

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