SCN1B

Gene Symbol SCN1B
Entrez Gene 6324
Alt Symbol ATFB13, BRGDA5, GEFSP1
Species Human
Gene Type protein-coding
Description sodium channel, voltage gated, type I beta subunit
Other Description sodium channel beta-1 subunit|sodium channel subunit beta-1|sodium channel, voltage-gated, type I, beta subunit
Swissprots Q5TZZ4 Q6TN97 Q07699
Accessions AAB97608 AAC41946 ABQ01236 Q07699 AK295477 BAG58404 AK313279 BAG36087 AY391842 AAR25552 BC021266 AAH21266 BC030193 BC067122 AAH67122 BC112922 AAI12923 BF194996 BM805468 BT019923 AAV38726 L10338 AAA60391 L16242 AAA61277 XM_005259144 XP_005259201 NM_001037 NP_001028 NM_199037 NP_950238
Function Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. {ECO:0000269|PubMed:14622265}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level). {ECO:0000269|PubMed:14622265}.
Top Pathways Adrenergic signaling in cardiomyocytes

Na Channel β1 Subunit (D4Z2N) Rabbit mAb - 13950 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4Z2N
Western blot analysis of extracts from mouse and rat brain membrane using Na Channel β1 Subunit (D4Z2N) Rabbit mAb.

Na Channel β1 Subunit (D9T5B) Rabbit mAb - 14684 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9T5B
Western blot analysis of human, mouse, and rat brain membrane extracts using Na Channel β1 Subunit (D9T5B) Rabbit mAb.

Na + CP type Iβ (Y-18) - sc-161902 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SCN1B antibody - ab107370 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab107370 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab107370 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SCN1B antibody - ab80390 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SCN1B antibody (ab80390) at 1 µg/ml (in 5% skim milk / PBS buffer) + HeLa cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SCN1B antibody - ab86931 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SCN1B antibody (ab86931) at 1 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat testicular tissue lysateLane 3 : MCF7 whole cell lysateLane 4 : HeLa whole cell lysateLane 5 : MM231 whole cell lysateLane 6 : HT1080 whole cell lysate

Anti-SCN1B antibody - ab133913 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SCN1B antibody (ab133913) at 1 µg/ml + Rat thymus lysate at 10 µg

Anti-SCN1B Antibody (N-Terminus) - LS-C132166 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (N-Terminus, Magnetic beads) - LS-C172070 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa63-90, APC) - LS-C268825 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa63-90, AP) - LS-C268824 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (N-Terminus, Sepharose) - LS-C172071 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa63-90, FITC) - LS-C268827 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa63-90, Biotin) - LS-C268826 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa63-90, PE) - LS-C268829 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa63-90, Azide-free, HRP) - LS-C268828 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (aa58-107) - LS-C151198 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SCN1B antibody Western Blot of Rat Thymus.

Anti-SCN1B Antibody (aa70-98) - LS-C324940 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B Antibody (N-Terminus) IHC-plus™ - LS-B11647 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SCN1B Antibody (aa63-90) - LS-C162899 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SCN1B Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-SCN1B Antibody (aa110-159) IHC-plus™ - LS-B11125 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SCN1B antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11125 concentration 10 ug/ml.

SCN1B Polyclonal Antibody - bs-6687R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN1B antibody produced in rabbit - SAB4300864 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-SCN1B (N-TERM) antibody produced in rabbit - SAB1303108 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SCN1B (N-Term): <B>Cat. No. SAB1303108 </B>: SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (35 μg/lane).

Anti-SCN1B antibody produced in rabbit - AV35028 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HeLa (<B>Cat. No. AV35028</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HeLa
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