ARF1
| Gene Symbol | ARF1 |
|---|---|
| Entrez Gene | 375 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADP-ribosylation factor 1 |
| Other Description | - |
| Swissprots | P84077 |
| Accessions | AAA35511 EAW69831 EAW69832 EAW69833 EAW69834 EAW69835 EAW69836 P84077 AF052179 AAC28623 AF055002 AAC09356 AF493881 AAM12595 AK000620 AK057838 AK057875 AK130737 AK293553 BAG57030 AK296020 BAG58790 AK297792 BAG60132 AM393261 CAL38139 AM393462 CAL38339 AM393595 CAL38472 AM393712 CAL38588 BC009247 AAH09247 BC010415 BC010429 AAH10429 BC011358 AAH11358 BF337061 BG421840 BM353046 BM844480 BQ935470 BQ949763 BT007393 AAP36057 M36340 AAA35552 M84326 AAA35512 NM_001024226 NP_001019397 NM_001024227 NP_001019398 NM_001024228 NP_001019399 NM_001658 NP_001649 |
| Function | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). |
| Subcellular Location | Golgi apparatus {ECO:0000269|PubMed:17555535}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17555535}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. |
| Top Pathways | Vibrio cholerae infection, Endocytosis, Legionellosis |
ARF1 CRISPR/Cas9 KO Plasmid (h) - sc-401608 from Santa Cruz Biotechnology
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ARF1 HDR Plasmid (h) - sc-401608-HDR from Santa Cruz Biotechnology
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ARF1 Double Nickase Plasmid (h) - sc-401608-NIC from Santa Cruz Biotechnology
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ARF1 Double Nickase Plasmid (h2) - sc-401608-NIC-2 from Santa Cruz Biotechnology
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ARF1 CRISPR Activation Plasmid (h) - sc-401608-ACT from Santa Cruz Biotechnology
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ARF1 CRISPR Activation Plasmid (h2) - sc-401608-ACT-2 from Santa Cruz Biotechnology
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ARF1 Lentiviral Activation Particles (h) - sc-401608-LAC from Santa Cruz Biotechnology
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ARF1 Lentiviral Activation Particles (h2) - sc-401608-LAC-2 from Santa Cruz Biotechnology
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ARF1 siRNA (h) - sc-105086 from Santa Cruz Biotechnology
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ARF1 shRNA Plasmid (h) - sc-105086-SH from Santa Cruz Biotechnology
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ARF1 shRNA (h) Lentiviral Particles - sc-105086-V from Santa Cruz Biotechnology
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ARF1 RNAi - H00000375-R01 from Novus Biologicals
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ARF1 RNAi - H00000375-R04 from Novus Biologicals
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MISSION® esiRNA - EHU144411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3387 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3387 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08493 from Sigma-Aldrich
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ARF1 siRNA (Human) - CRH0268 from Cohesion Biosciences
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ARF1 RNAi - H00000375-R02 from Novus Biologicals
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ARF1 RNAi - H00000375-R03 from Novus Biologicals
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ARF1 - MBS8229042 from MyBioSource
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shRNA set against Human ARF1 (NM_001658.3) - SHH239078 from Creative biogene
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shRNA set against Human ARF1(NM_001024226.1) - SHG068293 from Creative biogene
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Human ARF1 siRNA - orb260770 from Biorbyt
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ARF1 shRNA Plasmid (Human) - CHH0268 from Cohesion Biosciences
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